dc.contributor.author |
Quintana, R. |
|
dc.contributor.author |
Pons-Estel, G.J. |
|
dc.contributor.author |
Roberts, K. |
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dc.contributor.author |
Sacnún, M. |
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dc.contributor.author |
Serrano, R. |
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dc.contributor.author |
Nieto, R. |
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dc.contributor.author |
Conti, S. |
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dc.contributor.author |
Gervasoni, V. |
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dc.contributor.author |
Catoggio, L.J. |
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dc.contributor.author |
Soriano, E.R. |
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dc.contributor.author |
Scolnik, M. |
|
dc.contributor.author |
García, M.A. |
|
dc.contributor.author |
Alvarellos, A. |
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dc.contributor.author |
Saurit, V. |
|
dc.contributor.author |
Berbotto, G.A. |
|
dc.contributor.author |
Sato, E.I. |
|
dc.contributor.author |
Costallat, L.T.L. |
|
dc.contributor.author |
Neto, E.F.B. |
|
dc.contributor.author |
Bonfa, E. |
|
dc.contributor.author |
Xavier, R.M. |
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dc.contributor.author |
de Oliveira e Silva Montandon, A.C. |
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dc.contributor.author |
Molina-Restrepo, J.F. |
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dc.contributor.author |
Iglesias-Gamarra, A. |
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dc.contributor.author |
Guibert-Toledano, M. |
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dc.contributor.author |
Reyes-Llerena, G.A. |
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dc.contributor.author |
Massardo, L. |
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dc.contributor.author |
Neira, O.J. |
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dc.contributor.author |
Cardiel, M.H. |
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dc.contributor.author |
Barile-Fabris, L.A. |
|
dc.contributor.author |
Amigo, M.-C. |
|
dc.contributor.author |
Silveira, L.H. |
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dc.contributor.author |
Torre, I.G.D.L. |
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dc.contributor.author |
Acevedo-Vásquez, E.M. |
|
dc.contributor.author |
Ugarte Gil, Manuel Francisco |
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dc.contributor.author |
Alfaro-Lozano, J.L. |
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dc.contributor.author |
Segami, M.I. |
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dc.contributor.author |
Chacón-Díaz, R. |
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dc.contributor.author |
Esteva-Spinetti, M.H. |
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dc.contributor.author |
Gomez-Puerta, J.A. |
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dc.contributor.author |
Alarcón, Graciela S. |
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dc.contributor.author |
Pons-Estel, B.A. |
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dc.date.accessioned |
2020-12-14T16:10:05Z |
|
dc.date.available |
2020-12-14T16:10:05Z |
|
dc.date.issued |
2020 |
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dc.identifier.uri |
https://hdl.handle.net/20.500.12866/8772 |
|
dc.description.abstract |
Objectives: This study aimed to compare the clinical features, damage accrual, and survival of patients with familial and sporadic systemic lupus erythematosus (SLE). Methods: A multi-ethnic, multinational Latin American SLE cohort was studied. Familial lupus was defined as patients with a first-degree SLE relative; these relatives were interviewed in person or by telephone. Clinical variables, disease activity, damage, and mortality were compared. Odds ratios (OR) and 95% confidence intervals (CI) were estimated. Hazard ratios (HR) were calculated using Cox proportional hazard adjusted for potential confounders for time to damage and mortality. Results: A total of 66 (5.6%) patients had familial lupus, and 1110 (94.4%) had sporadic lupus. Both groups were predominantly female, of comparable age, and of similar ethnic distribution. Discoid lupus (OR = 1.97; 95% CI 1.08–3.60) and neurologic disorder (OR = 1.65; 95% CI 1.00–2.73) were significantly associated with familial SLE; pericarditis was negatively associated (OR = 0.35; 95% CI 0.14–0.87). The SLE Disease Activity Index and Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) were similar in both groups, although the neuropsychiatric (45.4% vs. 33.5%; p = 0.04) and musculoskeletal (6.1% vs. 1.9%; p = 0.02) domains of the SDI were more frequent in familial lupus. They were not retained in the Cox models (by domains). Familial lupus was not significantly associated with damage accrual (HR = 0.69; 95% CI 0.30–1.55) or mortality (HR = 1.23; 95% CI 0.26–4.81). Conclusion: Familial SLE is not characterized by a more severe form of disease than sporadic lupus. We also observed that familial SLE has a higher frequency of discoid lupus and neurologic manifestations and a lower frequency of pericarditis. |
en_US |
dc.language.iso |
eng |
|
dc.publisher |
SAGE Publications |
|
dc.relation.ispartofseries |
Lupus |
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dc.rights |
info:eu-repo/semantics/restrictedAccess |
|
dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
|
dc.subject |
Clinical features |
en_US |
dc.subject |
damage accrual |
en_US |
dc.subject |
patients |
en_US |
dc.subject |
systemic lupus erythematosus |
en_US |
dc.title |
Clinical features, damage accrual, and survival in patients with familial systemic lupus erythematosus: data from a multi-ethnic, multinational Latin American lupus cohort |
en_US |
dc.type |
info:eu-repo/semantics/article |
|
dc.identifier.doi |
https://doi.org/10.1177/0961203320935184 |
|
dc.subject.ocde |
https://purl.org/pe-repo/ocde/ford#3.02.17 |
|
dc.relation.issn |
1477-0962 |
|