Mostrar el registro sencillo del ítem
dc.contributor.author | Quintana, R. | |
dc.contributor.author | Pons-Estel, G.J. | |
dc.contributor.author | Roberts, K. | |
dc.contributor.author | Sacnún, M. | |
dc.contributor.author | Serrano, R. | |
dc.contributor.author | Nieto, R. | |
dc.contributor.author | Conti, S. | |
dc.contributor.author | Gervasoni, V. | |
dc.contributor.author | Catoggio, L.J. | |
dc.contributor.author | Soriano, E.R. | |
dc.contributor.author | Scolnik, M. | |
dc.contributor.author | García, M.A. | |
dc.contributor.author | Alvarellos, A. | |
dc.contributor.author | Saurit, V. | |
dc.contributor.author | Berbotto, G.A. | |
dc.contributor.author | Sato, E.I. | |
dc.contributor.author | Costallat, L.T.L. | |
dc.contributor.author | Neto, E.F.B. | |
dc.contributor.author | Bonfa, E. | |
dc.contributor.author | Xavier, R.M. | |
dc.contributor.author | de Oliveira e Silva Montandon, A.C. | |
dc.contributor.author | Molina-Restrepo, J.F. | |
dc.contributor.author | Iglesias-Gamarra, A. | |
dc.contributor.author | Guibert-Toledano, M. | |
dc.contributor.author | Reyes-Llerena, G.A. | |
dc.contributor.author | Massardo, L. | |
dc.contributor.author | Neira, O.J. | |
dc.contributor.author | Cardiel, M.H. | |
dc.contributor.author | Barile-Fabris, L.A. | |
dc.contributor.author | Amigo, M.-C. | |
dc.contributor.author | Silveira, L.H. | |
dc.contributor.author | Torre, I.G.D.L. | |
dc.contributor.author | Acevedo-Vásquez, E.M. | |
dc.contributor.author | Ugarte Gil, Manuel Francisco | |
dc.contributor.author | Alfaro-Lozano, J.L. | |
dc.contributor.author | Segami, M.I. | |
dc.contributor.author | Chacón-Díaz, R. | |
dc.contributor.author | Esteva-Spinetti, M.H. | |
dc.contributor.author | Gomez-Puerta, J.A. | |
dc.contributor.author | Alarcón, Graciela S. | |
dc.contributor.author | Pons-Estel, B.A. | |
dc.date.accessioned | 2020-12-14T16:10:05Z | |
dc.date.available | 2020-12-14T16:10:05Z | |
dc.date.issued | 2020 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12866/8772 | |
dc.description.abstract | Objectives: This study aimed to compare the clinical features, damage accrual, and survival of patients with familial and sporadic systemic lupus erythematosus (SLE). Methods: A multi-ethnic, multinational Latin American SLE cohort was studied. Familial lupus was defined as patients with a first-degree SLE relative; these relatives were interviewed in person or by telephone. Clinical variables, disease activity, damage, and mortality were compared. Odds ratios (OR) and 95% confidence intervals (CI) were estimated. Hazard ratios (HR) were calculated using Cox proportional hazard adjusted for potential confounders for time to damage and mortality. Results: A total of 66 (5.6%) patients had familial lupus, and 1110 (94.4%) had sporadic lupus. Both groups were predominantly female, of comparable age, and of similar ethnic distribution. Discoid lupus (OR = 1.97; 95% CI 1.08–3.60) and neurologic disorder (OR = 1.65; 95% CI 1.00–2.73) were significantly associated with familial SLE; pericarditis was negatively associated (OR = 0.35; 95% CI 0.14–0.87). The SLE Disease Activity Index and Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) were similar in both groups, although the neuropsychiatric (45.4% vs. 33.5%; p = 0.04) and musculoskeletal (6.1% vs. 1.9%; p = 0.02) domains of the SDI were more frequent in familial lupus. They were not retained in the Cox models (by domains). Familial lupus was not significantly associated with damage accrual (HR = 0.69; 95% CI 0.30–1.55) or mortality (HR = 1.23; 95% CI 0.26–4.81). Conclusion: Familial SLE is not characterized by a more severe form of disease than sporadic lupus. We also observed that familial SLE has a higher frequency of discoid lupus and neurologic manifestations and a lower frequency of pericarditis. | en_US |
dc.language.iso | eng | |
dc.publisher | SAGE Publications | |
dc.relation.ispartofseries | Lupus | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
dc.subject | Clinical features | en_US |
dc.subject | damage accrual | en_US |
dc.subject | patients | en_US |
dc.subject | systemic lupus erythematosus | en_US |
dc.title | Clinical features, damage accrual, and survival in patients with familial systemic lupus erythematosus: data from a multi-ethnic, multinational Latin American lupus cohort | en_US |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | https://doi.org/10.1177/0961203320935184 | |
dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.02.17 | |
dc.relation.issn | 1477-0962 |
Ficheros | Tamaño | Formato | Ver |
---|---|---|---|
No hay ficheros asociados a este ítem. |