Universidad Peruana Cayetano Heredia

Clinical features, damage accrual, and survival in patients with familial systemic lupus erythematosus: data from a multi-ethnic, multinational Latin American lupus cohort

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dc.contributor.author Quintana, R.
dc.contributor.author Pons-Estel, G.J.
dc.contributor.author Roberts, K.
dc.contributor.author Sacnún, M.
dc.contributor.author Serrano, R.
dc.contributor.author Nieto, R.
dc.contributor.author Conti, S.
dc.contributor.author Gervasoni, V.
dc.contributor.author Catoggio, L.J.
dc.contributor.author Soriano, E.R.
dc.contributor.author Scolnik, M.
dc.contributor.author García, M.A.
dc.contributor.author Alvarellos, A.
dc.contributor.author Saurit, V.
dc.contributor.author Berbotto, G.A.
dc.contributor.author Sato, E.I.
dc.contributor.author Costallat, L.T.L.
dc.contributor.author Neto, E.F.B.
dc.contributor.author Bonfa, E.
dc.contributor.author Xavier, R.M.
dc.contributor.author de Oliveira e Silva Montandon, A.C.
dc.contributor.author Molina-Restrepo, J.F.
dc.contributor.author Iglesias-Gamarra, A.
dc.contributor.author Guibert-Toledano, M.
dc.contributor.author Reyes-Llerena, G.A.
dc.contributor.author Massardo, L.
dc.contributor.author Neira, O.J.
dc.contributor.author Cardiel, M.H.
dc.contributor.author Barile-Fabris, L.A.
dc.contributor.author Amigo, M.-C.
dc.contributor.author Silveira, L.H.
dc.contributor.author Torre, I.G.D.L.
dc.contributor.author Acevedo-Vásquez, E.M.
dc.contributor.author Ugarte Gil, Manuel Francisco
dc.contributor.author Alfaro-Lozano, J.L.
dc.contributor.author Segami, M.I.
dc.contributor.author Chacón-Díaz, R.
dc.contributor.author Esteva-Spinetti, M.H.
dc.contributor.author Gomez-Puerta, J.A.
dc.contributor.author Alarcón, Graciela S.
dc.contributor.author Pons-Estel, B.A.
dc.date.accessioned 2020-12-14T16:10:05Z
dc.date.available 2020-12-14T16:10:05Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8772
dc.description.abstract Objectives: This study aimed to compare the clinical features, damage accrual, and survival of patients with familial and sporadic systemic lupus erythematosus (SLE). Methods: A multi-ethnic, multinational Latin American SLE cohort was studied. Familial lupus was defined as patients with a first-degree SLE relative; these relatives were interviewed in person or by telephone. Clinical variables, disease activity, damage, and mortality were compared. Odds ratios (OR) and 95% confidence intervals (CI) were estimated. Hazard ratios (HR) were calculated using Cox proportional hazard adjusted for potential confounders for time to damage and mortality. Results: A total of 66 (5.6%) patients had familial lupus, and 1110 (94.4%) had sporadic lupus. Both groups were predominantly female, of comparable age, and of similar ethnic distribution. Discoid lupus (OR = 1.97; 95% CI 1.08–3.60) and neurologic disorder (OR = 1.65; 95% CI 1.00–2.73) were significantly associated with familial SLE; pericarditis was negatively associated (OR = 0.35; 95% CI 0.14–0.87). The SLE Disease Activity Index and Systemic Lupus International Collaborating Clinics/American College of Rheumatology Damage Index (SDI) were similar in both groups, although the neuropsychiatric (45.4% vs. 33.5%; p = 0.04) and musculoskeletal (6.1% vs. 1.9%; p = 0.02) domains of the SDI were more frequent in familial lupus. They were not retained in the Cox models (by domains). Familial lupus was not significantly associated with damage accrual (HR = 0.69; 95% CI 0.30–1.55) or mortality (HR = 1.23; 95% CI 0.26–4.81). Conclusion: Familial SLE is not characterized by a more severe form of disease than sporadic lupus. We also observed that familial SLE has a higher frequency of discoid lupus and neurologic manifestations and a lower frequency of pericarditis. en_US
dc.language.iso eng
dc.publisher SAGE Publications
dc.relation.ispartofseries Lupus
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Clinical features en_US
dc.subject damage accrual en_US
dc.subject patients en_US
dc.subject systemic lupus erythematosus en_US
dc.title Clinical features, damage accrual, and survival in patients with familial systemic lupus erythematosus: data from a multi-ethnic, multinational Latin American lupus cohort en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1177/0961203320935184
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.17
dc.relation.issn 1477-0962


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