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Natural Polymorphisms in Mycobacterium tuberculosis Conferring Resistance to Delamanid in Drug-Naive Patients

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dc.contributor.author Reichmuth, M.L.
dc.contributor.author Hömke, R.
dc.contributor.author Zürcher, K.
dc.contributor.author Sander, P.
dc.contributor.author Avihingsanon, A.
dc.contributor.author Collantes, J.
dc.contributor.author Loiseau, C.
dc.contributor.author Borrell, S.
dc.contributor.author Reinhard, M.
dc.contributor.author Wilkinson, R.J.
dc.contributor.author Yotebieng, M.
dc.contributor.author Fenner, L.
dc.contributor.author Böttger, E.C.
dc.contributor.author Gagneux, S.
dc.contributor.author Egger, M.
dc.contributor.author Keller, P.M.
dc.contributor.author International epidemiology Databases to Evaluate AIDS (IeDEA)
dc.date.accessioned 2020-12-14T16:10:06Z
dc.date.available 2020-12-14T16:10:06Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8778
dc.description.abstract Mutations in the genes of the F420 signaling pathway of Mycobacterium tuberculosis complex, including dnn, fgd1, fbiA, fbiB, fbiC, and fbiD, can lead to delamanid resistance. We searched for such mutations among 129 M. tuberculosis strains from Asia, South America, and Africa using whole-genome sequencing; 70 (54%) strains had at least one mutation in one of the genes. For 10 strains with mutations, we determined the MIC of delamanid. We found one strain from a delamanid-naive patient carrying the natural polymorphism Tyr29del (ddn) that was associated with a critical delamanid MIC. en_US
dc.language.iso eng
dc.publisher American Society for Microbiology
dc.relation.ispartof urn:issn:1098-6596
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject UNAVAILABLE en_US
dc.title Natural Polymorphisms in Mycobacterium tuberculosis Conferring Resistance to Delamanid in Drug-Naive Patients en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1128/AAC.00513-20
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.05


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