Universidad Peruana Cayetano Heredia

Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population

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dc.contributor.author Romero-Hidalgo, S.
dc.contributor.author Flores-Rivera, J.
dc.contributor.author Rivas-Alonso, V.
dc.contributor.author Barquera, R.
dc.contributor.author Villarreal-Molina, M.T.
dc.contributor.author Antuna-Puente, B.
dc.contributor.author Macias-Kauffer, L.R.
dc.contributor.author Villalobos-Comparán, M.
dc.contributor.author Ortiz-Maldonado, J.
dc.contributor.author Yu, N.
dc.contributor.author Lebedeva, T.V.
dc.contributor.author Alosco, S.M.
dc.contributor.author García-Rodríguez, J.D.
dc.contributor.author González-Torres, C.
dc.contributor.author Rosas-Madrigal, S.
dc.contributor.author Ordoñez, G.
dc.contributor.author Guerrero-Camacho, J.L.
dc.contributor.author Treviño-Frenk, I.
dc.contributor.author Escamilla-Tilch, M.
dc.contributor.author García-Lechuga, M.
dc.contributor.author Tovar-Méndez, V.H.
dc.contributor.author Pacheco-Ubaldo, H.
dc.contributor.author Acuña-Alonzo, V.
dc.contributor.author Bortolini, M.-C.
dc.contributor.author Gallo López-Aliaga, Carla Maria
dc.contributor.author Bedoya, G.
dc.contributor.author Rothhammer, F.
dc.contributor.author González-Jose, R.
dc.contributor.author Ruiz-Linares, A.
dc.contributor.author Canizales-Quinteros, S.
dc.contributor.author Yunis, E.
dc.contributor.author Granados, J.
dc.contributor.author Corona, T.
dc.date.accessioned 2020-12-14T16:10:07Z
dc.date.available 2020-12-14T16:10:07Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8784
dc.description.abstract Neuromyelitis Optica (NMO) is an autoimmune disease with a higher prevalence in non-European populations. Because the Mexican population resulted from the admixture between mainly Native American and European populations, we used genome-wide microarray, HLA high-resolution typing and AQP4 gene sequencing data to analyze genetic ancestry and to seek genetic variants conferring NMO susceptibility in admixed Mexican patients. A total of 164 Mexican NMO patients and 1,208 controls were included. On average, NMO patients had a higher proportion of Native American ancestry than controls (68.1% vs 58.6%; p = 5 × 10–6). GWAS identified a HLA region associated with NMO, led by rs9272219 (OR = 2.48, P = 8 × 10–10). Class II HLA alleles HLA-DQB1*03:01, -DRB1*08:02, -DRB1*16:02, -DRB1*14:06 and -DQB1*04:02 showed the most significant associations with NMO risk. Local ancestry estimates suggest that all the NMO-associated alleles within the HLA region are of Native American origin. No novel or missense variants in the AQP4 gene were found in Mexican patients with NMO or multiple sclerosis. To our knowledge, this is the first study supporting the notion that Native American ancestry significantly contributes to NMO susceptibility in an admixed population, and is consistent with differences in NMO epidemiology in Mexico and Latin America. en_US
dc.language.iso eng
dc.publisher Springer Nature
dc.relation.ispartofseries Scientific Reports
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Genetics en_US
dc.subject Immunology en_US
dc.subject Medical research en_US
dc.subject Risk factors en_US
dc.title Native American ancestry significantly contributes to neuromyelitis optica susceptibility in the admixed Mexican population en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1038/s41598-020-69224-3
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.02
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.03
dc.relation.issn 2045-2322


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