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Anti–MSP-10 IgG indicates recent exposure to Plasmodium vivax infection in the Peruvian Amazon

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dc.contributor.author Rosas-Aguirre, A.
dc.contributor.author Patra, K.P.
dc.contributor.author Calderón, M.
dc.contributor.author Torres, K.
dc.contributor.author Gamboa, D.
dc.contributor.author Arocutipa, E.
dc.contributor.author Málaga, E.
dc.contributor.author Garro, K.
dc.contributor.author Fernández, C.
dc.contributor.author Trompeter, G.
dc.contributor.author Alnasser, Y.
dc.contributor.author Llanos-Cuentas, A.
dc.contributor.author Gilman, R.H.
dc.contributor.author Vinetz, J.M.
dc.date.accessioned 2020-12-14T16:10:08Z
dc.date.available 2020-12-14T16:10:08Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8786
dc.description.abstract BACKGROUND. Serological tools for the accurate detection of recent malaria exposure are needed to guide and monitor malaria control efforts. IgG responses against Plasmodium vivax and P. falciparum merozoite surface protein-10 (MSP10) were measured as a potential way to identify recent malaria exposure in the Peruvian Amazon. METHODS. A field-based study included 470 participants in a longitudinal cohort who completed a comprehensive evaluation: light microscopy and PCR on enrollment, at least 1 monthly follow-up by light microscopy, a second PCR, and serum and dried blood spots for serological analysis at the end of the follow-up. IgG titers against novel mammalian cell–produced recombinant PvMSP10 and PfMSP10 were determined by ELISA. RESULTS. During the follow-up period, 205 participants were infected, including 171 with P. vivax, 26 with P. falciparum, 6 with infections by both species but at different times, and 2 with mixed infections. Exposure to P. vivax was more accurately identified when serological responses to PvMSP10 were obtained from serum (sensitivity, 58.1%; specificity, 81.8%; AUC: 0.76) than from dried blood spots (sensitivity, 35.2; specificity, 83.5%; AUC: 0.64) (PAUC < 0.001). Sensitivity was highest (serum, 82.9%; dried blood spot, 45.7%) with confirmed P. vivax infections occurring 7–30 days before sample collection; sensitivity decreased significantly in relation to time since last documented infection. PvMSP10 serological data did not show evidence of interspecies cross-reactivity. Anti-PfMSP10 responses poorly discriminated between P. falciparum–exposed and nonexposed individuals (AUC = 0.59; P > 0.05). CONCLUSION. Anti-PvMSP10 IgG indicates recent exposure to P. vivax at the population level in the Amazon region. Serum, not dried blood spots, should be used for such serological tests. FUNDING. Cooperative agreement U19AI089681 from the United States Public Health Service, NIH/ National Institute of Allergy and Infectious Diseases, as the Amazonian International Center of Excellence in Malaria Research. en_US
dc.language.iso eng
dc.publisher American Society for Clinical Investigation
dc.relation.ispartof urn:issn:2379-3708
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject UNAVAILABLE en_US
dc.title Anti–MSP-10 IgG indicates recent exposure to Plasmodium vivax infection in the Peruvian Amazon en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1172/jci.insight.130769
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00

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