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Human plasmodium vivax diversity, population structure and evolutionary origin

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dc.contributor.author Rougeron, V.
dc.contributor.author Elguero, E.
dc.contributor.author Arnathau, C.
dc.contributor.author Hidalgo, B.A.
dc.contributor.author Durand, P.
dc.contributor.author Houze, S.
dc.contributor.author Berry, A.
dc.contributor.author Zakeri, S.
dc.contributor.author Haque, R.
dc.contributor.author Alam, M.S.
dc.contributor.author Nosten, F.
dc.contributor.author Severini, C.
dc.contributor.author Woldearegai, T.G.
dc.contributor.author Mordmüller, B.
dc.contributor.author Kremsner, P.G.
dc.contributor.author González-Cerón, L.
dc.contributor.author Fontecha, G.
dc.contributor.author Gamboa Vilela, Dionicia Baziliza
dc.contributor.author Musset, L.
dc.contributor.author Legrand, E.
dc.contributor.author Noya, O.
dc.contributor.author Pumpaibool, T.
dc.contributor.author Harnyuttanakorn, P.
dc.contributor.author Lekweiry, K.M.
dc.contributor.author Albsheer, M.M.
dc.contributor.author Hamid, M.M.A.
dc.contributor.author Boukary, A.O.M.S.
dc.contributor.author Trape, J.-F.
dc.contributor.author Renaud, F.
dc.contributor.author Prugnolle, F.
dc.date.accessioned 2020-12-14T16:10:08Z
dc.date.available 2020-12-14T16:10:08Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8787
dc.description.abstract More than 200 million malaria clinical cases are reported each year due to Plasmodium vivax, the most widespread Plasmodium species in the world. This species has been neglected and understudied for a long time, due to its lower mortality in comparison with Plasmodium falciparum. A renewed interest has emerged in the past decade with the dis-covery of antimalarial drug resistance and of severe and even fatal human cases. Nonethe-less, today there are still significant gaps in our understanding of the population genetics and evolutionary history of P. vivax, particularly because of a lack of genetic data from Africa. To address these gaps, we genotyped 14 microsatellite loci in 834 samples obtained from 28 locations in 20 countries from around the world. We discuss the worldwide population genetic structure and diversity and the evolutionary origin of P. vivax in the world and its introduction into the Americas. This study demonstrates the importance of conducting genome-wide analyses of P. vivax in order to unravel its complex evolutionary history. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS Neglected Tropical Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Plasmodium en_US
dc.subject Population genetics en_US
dc.subject Africa en_US
dc.subject Asia en_US
dc.subject Species diversity en_US
dc.subject Microsatellite loci en_US
dc.subject Evolutionary genetics en_US
dc.subject Parasite evolution en_US
dc.title Human plasmodium vivax diversity, population structure and evolutionary origin en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pntd.0008072
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1935-2735


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