Universidad Peruana Cayetano Heredia
Association between tuberculosis and depression on negative outcomes of tuberculosis treatment: A systematic review and meta-analysis
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| dc.contributor.author | Ruiz-Grosso, P. | |
| dc.contributor.author | Cachay Figueroa, Rodrigo Antonio | |
| dc.contributor.author | De La Flor, A. | |
| dc.contributor.author | Schwalb Calderon, Alvaro | |
| dc.contributor.author | Ugarte Gil, Cesar Augusto | |
| dc.date.accessioned | 2020-12-14T16:10:09Z | |
| dc.date.available | 2020-12-14T16:10:09Z | |
| dc.date.issued | 2020 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12866/8790 | |
| dc.description.abstract | Background: Depression is a common comorbidity of tuberculosis (TB) and is associated with poor adherence to treatment of multiple disorders. We conducted a systematic review to synthesize the existing evidence on the relationship between depression and negative outcomes of TB treatment. Methods: We systematically reviewed studies that evaluated depressive symptoms (DS) directly or indirectly through psychological distress (PD) and measured negative treatment outcomes of drug-sensitive pulmonary TB, defined as death, loss to follow-up, or non-adherence. Sources included PubMed, Global Health Library, Embase, Scopus and Web of Science from inception to August 2019. Results: Of the 2,970 studies initially identified, eight articles were eligible for inclusion and two were used for the primary outcome meta-analysis. We found a strong association between DS and negative TB treatment outcomes (OR = 4.26; CI95%:2.33-7.79; I2 = 0%). DS were also associated with loss to follow-up (OR = 8.70; CI95%:6.50-11.64; I2 = 0%) and death (OR = 2.85; CI95%:1.52-5.36; I2 = 0%). Non-adherence was not associated with DS and PD (OR = 1.34; CI95%:0.70-2.72; I2 = 94.36) or PD alone (OR = 0.92; CI95%:0.81-1.05; I2 = 0%). Conclusions: DS are associated with the negative TB treatment outcomes of death and loss to follow-up. Considerable heterogeneity exists in the definition of depression and outcomes such as non-adherence across the limited number of studies on this topic. | en_US |
| dc.description.sponsorship | Este trabajo fue parcialmente por la beca FONDECYT/CIENCIACTIVA [EF033-235-2015]. | es_PE |
| dc.language.iso | eng | |
| dc.publisher | Public Library of Science | |
| dc.relation.ispartofseries | PLoS ONE | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
| dc.subject | Depression | en_US |
| dc.subject | Tuberculosis | en_US |
| dc.subject | Metaanalysis | en_US |
| dc.subject | Clinical psychology | en_US |
| dc.subject | Medical risk factors | en_US |
| dc.subject | Systematic reviews | en_US |
| dc.subject | Database searching | en_US |
| dc.subject | Global health | en_US |
| dc.title | Association between tuberculosis and depression on negative outcomes of tuberculosis treatment: A systematic review and meta-analysis | en_US |
| dc.type | info:eu-repo/semantics/review | |
| dc.identifier.doi | https://doi.org/10.1371/journal.pone.0227472 | |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.02.07 | |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#5.01.00 | |
| dc.relation.issn | 1932-6203 |
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