DSpace Repository

Methylprednisolone pulse therapy: An alternative management of severe COVID-19

Show simple item record

dc.contributor.author Sauñe, P.M.
dc.contributor.author Bryce-Alberti, M.
dc.contributor.author Portmann Baracco, Arianna Sibila
dc.contributor.author Accinelli Tanaka, Roberto Alfonso
dc.date.accessioned 2020-12-14T16:10:11Z
dc.date.available 2020-12-14T16:10:11Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8799
dc.description.abstract We present two cases of severe COVID-19 that were rejected by medical institutions. The management of the disease was done at home with methylprednisolone (MP) pulse therapy for three days. This resulted in a favorable evolution and resolution of most symptoms. COVID-19 infection presents as asymptomatic disease, non-severe symptomatic disease, and severe respiratory inflammatory disease. The first two forms are dependent on viral response and a “cytokine storm” is responsible for the progression into severe disease. Glucocorticoids (GC) reduce inflammation by different mechanism depending of their concentration. Pulses lead to overall apoptosis of immune cells. Studies using pulse MP as treatment for SARS-CoV-1 showed clinical improvement and decreased incidence of ARDS compared with patients who received low dose steroid treatment. Inhibition of excessive inflammation through timely administration of GC in the early stage of inflammatory cytokine storm effectively prevents the occurrence of ARDS. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Respiratory Medicine Case Reports
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject COVID-19 en_US
dc.subject Cytokine storm en_US
dc.subject Treatment en_US
dc.subject Pulse therapy en_US
dc.subject Methylprednisolone en_US
dc.title Methylprednisolone pulse therapy: An alternative management of severe COVID-19 en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.rmcr.2020.101221
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.07
dc.relation.issn 2213-0071


Files in this item

Files Size Format View

There are no files associated with this item.

This item appears in the following Collection(s)

Show simple item record

info:eu-repo/semantics/restrictedAccess Except where otherwise noted, this item's license is described as info:eu-repo/semantics/restrictedAccess

Search DSpace


Browse

My Account

Statistics