dc.contributor.author |
Schwalb Calderon, Alvaro |
|
dc.contributor.author |
Pérez-Muto, V. |
|
dc.contributor.author |
Cachay Figueroa, Rodrigo Antonio |
|
dc.contributor.author |
Tipismana, M. |
|
dc.contributor.author |
Álvarez, C. |
|
dc.contributor.author |
Mejía Cordero, Fernando Alonso |
|
dc.contributor.author |
González Lagos, Elsa Violeta |
|
dc.contributor.author |
Gotuzzo Herencia, José Eduardo |
|
dc.date.accessioned |
2020-12-14T16:10:12Z |
|
dc.date.available |
2020-12-14T16:10:12Z |
|
dc.date.issued |
2020 |
|
dc.identifier.uri |
https://hdl.handle.net/20.500.12866/8803 |
|
dc.description.abstract |
Background: Vertical transmission of HTLV-1 could lead to the early development of HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). This significantly affects quality of life and increases morbimortality. Objective: To describe the epidemiological and clinical characteristics of patients with early-onset HAM/TSP, defined as disease onset before 20 years of age. Methods: This is a retrospective study from an HTLV-1 clinical cohort between 1989 and 2019. We searched for medical records of patients with (1) diagnosis of HTLV-1 infection using two ELISA and/or one Western blot, (2) clinical diagnosis of HAM/TSP by neurological assessment, and (3) HAM/TSP symptom-onset before 20 years of age. Results: A total of 38 cases were identified in the cohort; 25 were female (66%). The median age of onset was 14 years old. 31 (82%) cases had HTLV-1 testing done among family members; 22 out of 25 tested mothers (88%) were HTLV-1 positive. Most patients (27/34) were breastfed for more than one year. Disease progression measured through EDSS and IPEC-1 showed an upward trend towards worsening spasticity with 18 patients (47%) eventually requiring mobility aids. Conclusions: Cases of early-onset HAM/TSP are not of rare occurrence, which translates into many more years of dependency, the use of mobility aids, and increased overall morbidity. |
en_US |
dc.language.iso |
eng |
|
dc.publisher |
MDPI |
|
dc.relation.ispartofseries |
Pathogens |
|
dc.rights |
info:eu-repo/semantics/restrictedAccess |
|
dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
|
dc.subject |
HAM/TSP |
en_US |
dc.subject |
myelopathy |
en_US |
dc.subject |
paraparesis |
en_US |
dc.subject |
chronic infection |
en_US |
dc.subject |
inflammation |
en_US |
dc.title |
Early-onset HTLV-1-associated myelopathy/tropical spastic paraparesis |
en_US |
dc.type |
info:eu-repo/semantics/article |
|
dc.identifier.doi |
https://doi.org/10.3390/pathogens9060450 |
|
dc.subject.ocde |
https://purl.org/pe-repo/ocde/ford#3.01.09 |
|
dc.relation.issn |
2076-0817 |
|