dc.contributor.author |
Seclén, Segundo N. |
|
dc.contributor.author |
Nuñez-Robles, E. |
|
dc.contributor.author |
Yovera-Aldana, M. |
|
dc.contributor.author |
Arias-Chumpitaz, A. |
|
dc.date.accessioned |
2020-12-14T16:10:12Z |
|
dc.date.available |
2020-12-14T16:10:12Z |
|
dc.date.issued |
2020 |
|
dc.identifier.uri |
https://hdl.handle.net/20.500.12866/8804 |
|
dc.description.abstract |
To investigate the cumulative incidence and mortality of COVID-19 and the prevalence of comorbidities such as diabetes, obesity and hypertension in regions with different altitude levels ranging from sea level to high altitude. Methodology: Analytical study in which we correlated secondary data obtained from reports of the Ministry of Health and National Institute for Statistics and Informatic. The cumulative incidence and mortality of COVID-19 in 25 peruvian regions is reported, together with its relationnship with altitude levels during March-July 2020 using Pearsońs correlation. We also aiming to assess the prevalence of diabetes, obesity and hypertension with altitude according to the ENDES 2018 data using Gamma statistics. Results: COVID-19 maintained an inverse correlation with higher rates in the coastal regions and lower rates with increasing altitude in the cumulative incidence (Pearson = −0.8, p < 0.000) and mortality (Pearson = −0.77, p < 0.000), adjusted gender and age. The prevalence of diabetes and obesity showed the same inverse correlation trend with altitude (Gamma p < 0.000) but not hypertension (Gamma p = 0.13) Conclusions: The data in Peru it is suggested that physiological adaptation in a hypoxic environment at high altitude may protect persons from the severe impact of acute infection caused by SARS-CoV-2. The reduction in cumulative incidence and mortality rates with increasing altitude is the main finding. Possible mechanisms such as a decreased expression of angiotensin-converting enzyme 2 (ACE2) and a lower virulence because of a high altitude environment, may explain this epidemiological features. In addition, the lower prevalence of diabetes, obesity and hypertension may establish a protective epidemiology against these disease. |
en_US |
dc.language.iso |
eng |
|
dc.publisher |
Elsevier |
|
dc.relation.ispartofseries |
Diabetes Research and Clinical Practice |
|
dc.rights |
info:eu-repo/semantics/restrictedAccess |
|
dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
|
dc.subject |
COVID-19 |
en_US |
dc.subject |
Altitude |
en_US |
dc.subject |
Incidence |
en_US |
dc.subject |
Mortality |
en_US |
dc.subject |
Prevalence |
en_US |
dc.subject |
Diabetes |
en_US |
dc.subject |
Hypertension |
en_US |
dc.subject |
Obesity |
en_US |
dc.subject |
ACE2 |
en_US |
dc.subject |
ENDES 2018 |
en_US |
dc.title |
Incidence of COVID-19 infection and prevalence of diabetes, obesity and hypertension according to altitude in Peruvian population |
en_US |
dc.type |
info:eu-repo/semantics/article |
|
dc.identifier.doi |
https://doi.org/10.1016/j.diabres.2020.108463 |
|
dc.subject.ocde |
https://purl.org/pe-repo/ocde/ford#3.02.18 |
|
dc.relation.issn |
1872-8227 |
|