Universidad Peruana Cayetano Heredia

Incidence of COVID-19 infection and prevalence of diabetes, obesity and hypertension according to altitude in Peruvian population

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dc.contributor.author Seclén, Segundo N.
dc.contributor.author Nuñez-Robles, E.
dc.contributor.author Yovera-Aldana, M.
dc.contributor.author Arias-Chumpitaz, A.
dc.date.accessioned 2020-12-14T16:10:12Z
dc.date.available 2020-12-14T16:10:12Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8804
dc.description.abstract To investigate the cumulative incidence and mortality of COVID-19 and the prevalence of comorbidities such as diabetes, obesity and hypertension in regions with different altitude levels ranging from sea level to high altitude. Methodology: Analytical study in which we correlated secondary data obtained from reports of the Ministry of Health and National Institute for Statistics and Informatic. The cumulative incidence and mortality of COVID-19 in 25 peruvian regions is reported, together with its relationnship with altitude levels during March-July 2020 using Pearsońs correlation. We also aiming to assess the prevalence of diabetes, obesity and hypertension with altitude according to the ENDES 2018 data using Gamma statistics. Results: COVID-19 maintained an inverse correlation with higher rates in the coastal regions and lower rates with increasing altitude in the cumulative incidence (Pearson = −0.8, p < 0.000) and mortality (Pearson = −0.77, p < 0.000), adjusted gender and age. The prevalence of diabetes and obesity showed the same inverse correlation trend with altitude (Gamma p < 0.000) but not hypertension (Gamma p = 0.13) Conclusions: The data in Peru it is suggested that physiological adaptation in a hypoxic environment at high altitude may protect persons from the severe impact of acute infection caused by SARS-CoV-2. The reduction in cumulative incidence and mortality rates with increasing altitude is the main finding. Possible mechanisms such as a decreased expression of angiotensin-converting enzyme 2 (ACE2) and a lower virulence because of a high altitude environment, may explain this epidemiological features. In addition, the lower prevalence of diabetes, obesity and hypertension may establish a protective epidemiology against these disease. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Diabetes Research and Clinical Practice
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject COVID-19 en_US
dc.subject Altitude en_US
dc.subject Incidence en_US
dc.subject Mortality en_US
dc.subject Prevalence en_US
dc.subject Diabetes en_US
dc.subject Hypertension en_US
dc.subject Obesity en_US
dc.subject ACE2 en_US
dc.subject ENDES 2018 en_US
dc.title Incidence of COVID-19 infection and prevalence of diabetes, obesity and hypertension according to altitude in Peruvian population en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.diabres.2020.108463
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.18
dc.relation.issn 1872-8227


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