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Demographic history and selection at HLA loci in Native Americans

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dc.contributor.author Single, R.M.
dc.contributor.author Meyer, D.
dc.contributor.author Nunes, K.
dc.contributor.author Francisco, R.S.
dc.contributor.author Hünemeier, T.
dc.contributor.author Maiers, M.
dc.contributor.author Hurley, C.K.
dc.contributor.author Bedoya, G.
dc.contributor.author Gallo, C.
dc.contributor.author Hurtado, A.M.
dc.contributor.author Llop, E.
dc.contributor.author Petzl-Erler, M.L.
dc.contributor.author Poletti, G.
dc.contributor.author Rothhammer, F.
dc.contributor.author Tsuneto, L.
dc.contributor.author Klitz, W.
dc.contributor.author Ruiz-Linares, A.
dc.date.accessioned 2020-12-14T16:10:14Z
dc.date.available 2020-12-14T16:10:14Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8810
dc.description.abstract The American continent was the last to be occupied by modern humans, and native populations bear the marks of recent expansions, bottlenecks, natural selection, and population substructure. Here we investigate how this demographic history has shaped genetic variation at the strongly selected HLA loci. In order to disentangle the relative contributions of selection and demography process, we assembled a dataset with genome-wide microsatellites and HLA-A, -B, -C, and -DRB1 typing data for a set of 424 Native American individuals. We find that demographic history explains a sizeable fraction of HLA variation, both within and among populations. A striking feature of HLA variation in the Americas is the existence of alleles which are present in the continent but either absent or very rare elsewhere in the world. We show that this feature is consistent with demographic history (i.e., the combination of changes in population size associated with bottlenecks and subsequent population expansions). However, signatures of selection at HLA loci are still visible, with significant evidence selection at deeper timescales for most loci and populations, as well as population differentiation at HLA loci exceeding that seen at neutral markers. en_US
dc.language.iso eng
dc.publisher PLoS
dc.relation.ispartof urn:issn:1932-6203
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject UNAVAILABLE en_US
dc.title Demographic history and selection at HLA loci in Native Americans en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pone.0241282
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#5.04.02
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.03

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