Demographic history and selection at HLA loci in Native Americans

Hurtado, A.M.; Poletti, G.; Bedoya, G.; Klitz, W.; Maiers, M.; Francisco, R.S.; Llop, E.; Meyer, D.; Nunes, K.; Hünemeier, T.; Hurley, C.K.; Rothhammer, F.; Ruiz-Linares, A.; Single, R.M.; Petzl-Erler, M.L.; Tsuneto, L.; Gallo López-Aliaga, Carla Maria

dc.contributor.author	Single, R.M.
dc.contributor.author	Meyer, D.
dc.contributor.author	Nunes, K.
dc.contributor.author	Francisco, R.S.
dc.contributor.author	Hünemeier, T.
dc.contributor.author	Maiers, M.
dc.contributor.author	Hurley, C.K.
dc.contributor.author	Bedoya, G.
dc.contributor.author	Gallo López-Aliaga, Carla Maria
dc.contributor.author	Hurtado, A.M.
dc.contributor.author	Llop, E.
dc.contributor.author	Petzl-Erler, M.L.
dc.contributor.author	Poletti, G.
dc.contributor.author	Rothhammer, F.
dc.contributor.author	Tsuneto, L.
dc.contributor.author	Klitz, W.
dc.contributor.author	Ruiz-Linares, A.
dc.date.accessioned	2020-12-14T16:10:14Z
dc.date.available	2020-12-14T16:10:14Z
dc.date.issued	2020
dc.identifier.uri	https://hdl.handle.net/20.500.12866/8810
dc.description.abstract	The American continent was the last to be occupied by modern humans, and native populations bear the marks of recent expansions, bottlenecks, natural selection, and population substructure. Here we investigate how this demographic history has shaped genetic variation at the strongly selected HLA loci. In order to disentangle the relative contributions of selection and demography process, we assembled a dataset with genome-wide microsatellites and HLA-A, -B, -C, and -DRB1 typing data for a set of 424 Native American individuals. We find that demographic history explains a sizeable fraction of HLA variation, both within and among populations. A striking feature of HLA variation in the Americas is the existence of alleles which are present in the continent but either absent or very rare elsewhere in the world. We show that this feature is consistent with demographic history (i.e., the combination of changes in population size associated with bottlenecks and subsequent population expansions). However, signatures of selection at HLA loci are still visible, with significant evidence selection at deeper timescales for most loci and populations, as well as population differentiation at HLA loci exceeding that seen at neutral markers.	en_US
dc.language.iso	eng
dc.publisher	Public Library of Science
dc.relation.ispartofseries	PLoS ONE
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject	Heterozygosity	en_US
dc.subject	Native American people	en_US
dc.subject	Genetic loci	en_US
dc.subject	Alleles	en_US
dc.subject	Natural selection	en_US
dc.subject	Homozygosity	en_US
dc.subject	Microsatellite loci	en_US
dc.subject	Population genetics	en_US
dc.title	Demographic history and selection at HLA loci in Native Americans	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1371/journal.pone.0241282
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#5.04.02
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#1.06.03
dc.relation.issn	1932-6203