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Effect of Ketamine/Propofol Admixture on Peri-Induction Hemodynamics: A Systematic Review and Meta-Analysis

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dc.contributor.author Smischney, N.J.
dc.contributor.author Seisa, M.O.
dc.contributor.author Morrow, A.S.
dc.contributor.author Ponce, O.J.
dc.contributor.author Wang, Z.
dc.contributor.author Alzuabi, M.
dc.contributor.author Heise, K.J.
dc.contributor.author Murad, M.H.
dc.date.accessioned 2020-12-14T16:10:14Z
dc.date.available 2020-12-14T16:10:14Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8811
dc.description.abstract To evaluate the effectiveness of an admixture of ketamine and propofol on peri-induction hemodynamics during airway manipulation, we searched electronic databases of randomized controlled trials from January 1, 2000, to October 17, 2018. Trial screening, selection, and data extraction were done independently by two reviewers with outcomes pooled across included trials using the random-effects model. We included 10 randomized trials (722 patients, mean age of 53.99 years, 39.96% female). American Society of Anesthesiologists physical status was reported in 9 trials with classes I and II representing the majority. Ketamine/propofol admixture was associated with a nonsignificant increase in heart rate (weighted mean difference, 3.36 beats per minute (95% CI, -0.88, 7.60), I2 = 88.6%), a statistically significant increase in systolic blood pressure (weighted mean difference, 9.67 mmHg (95% CI, 1.48, 17.86), I2 = 87.2%), a nonsignificant increase in diastolic blood pressure (weighted mean difference, 2.18 mmHg (95% CI, -2.82, 7.19), I2 = 73.1%), and a nonsignificant increase in mean arterial pressure (weighted mean difference, 3.28 mmHg (95% CI, -0.94, 7.49), I2 = 69.9%) compared to other agents. The risk of bias was high and the certainty of evidence was low. In conclusion, among patients undergoing airway manipulation and needing sedation, the use of a ketamine/propofol admixture may be associated with better hemodynamics compared to nonketamine/propofol sedation. en_US
dc.language.iso eng
dc.publisher Hindawi
dc.relation.ispartof urn:issn:1687-6970
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject UNAVAILABLE en_US
dc.title Effect of Ketamine/Propofol Admixture on Peri-Induction Hemodynamics: A Systematic Review and Meta-Analysis en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1155/2020/9637412
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.09
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.08


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