Adaptive Potential of the Heme Oxygenase/Carbon Monoxide Pathway During Hypoxia

Alves de Souza, R.W.; Heinrich, E.C.; Simonson, T.S.; Malhotra, A.; Otterbein, L.E.; Tift, M.S.; Weber, J.; Villafuerte, Francisco C.

dc.contributor.author	Tift, M.S.
dc.contributor.author	Alves de Souza, R.W.
dc.contributor.author	Weber, J.
dc.contributor.author	Heinrich, E.C.
dc.contributor.author	Villafuerte, Francisco C.
dc.contributor.author	Malhotra, A.
dc.contributor.author	Otterbein, L.E.
dc.contributor.author	Simonson, T.S.
dc.date.accessioned	2020-12-14T16:10:18Z
dc.date.available	2020-12-14T16:10:18Z
dc.date.issued	2020
dc.identifier.uri	https://hdl.handle.net/20.500.12866/8824
dc.description.abstract	Heme oxygenase (HO) enzymes catalyze heme into biliverdin, releasing carbon monoxide (CO) and iron into circulation. These byproducts of heme degradation can have potent cytoprotective effects in the face of stressors such as hypoxia and ischemia-reperfusion events. The potential for exogenous use of CO as a therapeutic agent has received increasing attention throughout the past few decades. Further, HO and CO are noted as putatively adaptive in diving mammals and certain high-altitude human populations that are frequently exposed to hypoxia and/or ischemia-reperfusion events, suggesting that HO and endogenous CO afford an evolutionary advantage for hypoxia tolerance and are critical in cell survival and injury avoidance. Our goal is to describe the importance of examining HO and CO in several systems, the physiological links, and the genetic factors that underlie variation in the HO/CO pathway. Finally, we emphasize the ways in which evolutionary perspectives may enhance our understanding of the HO/CO pathway in the context of diverse clinical settings.	en_US
dc.language.iso	eng
dc.publisher	Frontiers Media
dc.relation.ispartofseries	Frontiers in Physiology
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject	carbon monoxide	en_US
dc.subject	heme oxygenase	en_US
dc.subject	hypoxia	en_US
dc.subject	altitude	en_US
dc.subject	diving	en_US
dc.subject	evolution	en_US
dc.subject	cytoprotection	en_US
dc.title	Adaptive Potential of the Heme Oxygenase/Carbon Monoxide Pathway During Hypoxia	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.3389/fphys.2020.00886
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.01.08
dc.relation.issn	1664-042X