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Daphnanes diterpenes from the latex of Hura crepitans L. And activity against human colorectal cancer cells Caco-2

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dc.contributor.author Trinel, M.
dc.contributor.author Le Lamer, A.-C.
dc.contributor.author Jullian, V.
dc.contributor.author Jacquemin, D.
dc.contributor.author Graton, J.
dc.contributor.author Cristofoli, V.
dc.contributor.author Crossay, E.
dc.contributor.author Yassine, M.
dc.contributor.author Rolland, C.
dc.contributor.author Vergnolle, N.
dc.contributor.author Mejia, K.
dc.contributor.author Joel Cabanillas, B.
dc.contributor.author Racaud-Sultan, C.
dc.contributor.author Fabre, N.
dc.date.accessioned 2020-12-14T16:10:20Z
dc.date.available 2020-12-14T16:10:20Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8831
dc.description.abstract Hura crepitans (Euphorbiaceae) is a tree from South America that produces an irritant latex used as a fish poison. A bio-guided fractionation of an ethanolic extract of the latex led to the isolation and structural identification of three known daphnane-type diterpenes (1–3) including huratoxin (1), together with two new analogs (4, 5). Compound 1 was found to exhibit significant and selective cell growth inhibition against the colorectal cancer cell line Caco-2, with morphological modifications suggesting formations mimicking the intestinal crypt architecture. The underlying mechanism of 1 was further investigated, in comparison with 12-O-tetradecanoylphorbol-13-acetate (TPA), revealing two different mechanisms. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartof urn:issn:1090-2120
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject UNAVAILABLE en_US
dc.title Daphnanes diterpenes from the latex of Hura crepitans L. And activity against human colorectal cancer cells Caco-2 en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.bioorg.2020.104132
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.04.01 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.03 es_PE
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.04.01
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.03

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