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Elucidating the Mechanism of Trypanosoma cruzi Acquisition by Triatomine Insects: Evidence from a Large Field Survey of Triatoma infestans

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dc.contributor.author Tustin, A.W.
dc.contributor.author Castillo Neyra, Ricardo
dc.contributor.author Tamayo, L.D.
dc.contributor.author Salazar Sánchez, Renzo Sadath
dc.contributor.author Borini-Mayorí, K.
dc.contributor.author Levy, M.Z.
dc.date.accessioned 2020-12-14T16:10:20Z
dc.date.available 2020-12-14T16:10:20Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8833
dc.description.abstract Blood-sucking triatomine bugs transmit the protozoan parasite Trypanosoma cruzi, the etiologic agent of Chagas disease. We measured the prevalence of T. cruzi infection in 58,519 Triatoma infestans captured in residences in and near Arequipa, Peru. Among bugs from infected colonies, T. cruzi prevalence increased with stage from 12% in second instars to 36% in adults. Regression models demonstrated that the probability of parasite acquisition was roughly the same for each developmental stage. Prevalence increased by 5.9% with each additional stage. We postulate that the probability of acquiring the parasite may be related to the number of feeding events. Transmission of the parasite does not appear to be correlated with the amount of blood ingested during feeding. Similarly, other hypothesized transmission routes such as coprophagy fail to explain the observed pattern of prevalence. Our results could have implications for the feasibility of late-Acting control strategies that preferentially kill older insects. en_US
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartofseries Tropical Medicine and Infectious Disease
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Trypanosoma cruzi en_US
dc.subject Triatoma infestans en_US
dc.subject Chagas disease en_US
dc.subject parasite prevalence en_US
dc.subject coprophagy en_US
dc.title Elucidating the Mechanism of Trypanosoma cruzi Acquisition by Triatomine Insects: Evidence from a Large Field Survey of Triatoma infestans en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.3390/tropicalmed5020087
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 2414-6366


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