Universidad Peruana Cayetano Heredia

Effect of a natural supplement containing glucosinolates, phytosterols and citrus flavonoids on body weight and metabolic parameters in a menopausal murine model induced by bilateral ovariectomy

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dc.contributor.author Valdivia, M.
dc.contributor.author Soto Becerra, Percy
dc.contributor.author Laguna-Barraza, R.
dc.contributor.author Rojas, P.A.
dc.contributor.author Reyes-Mandujano, I.
dc.contributor.author Gonzáles-Reyes, P.
dc.contributor.author Temoche, H.
dc.contributor.author Timoteo, O.S.
dc.contributor.author Lugo-Martinez, G.
dc.contributor.author Calzada-Mendoza, C.C.
dc.contributor.author Mezones-Holguin, E.
dc.date.accessioned 2020-12-14T16:10:22Z
dc.date.available 2020-12-14T16:10:22Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8837
dc.description.abstract Objective: To evaluate the effect of a herbal preparation containing glucosinolates, phytosterols and citrus flavonoids (supplement) on body weight and metabolic parameters usually impaired by menopause. Methods: A pre-clinical experimental study carried out in twenty-five Swiss strain mice (Mus musculus) randomly distributed (1:1:1:1:1 ratio) to five groups to receive for ten weeks: (1) oral gelatinized maca extract 0.5625 mg/kg/day + bilateral ovariectomy (Maca + OVX); (2) oral supplement 0.5625 mg/kg/day + bilateral ovariectomy (S1 + OVX); (3) oral supplement 1.6875 mg/kg/day + bilateral ovariectomy (S2 + OVX); (4) oral saline 100 µl/kg/day + bilateral ovariectomy (OVX); and (5) oral saline 100 µl/kg/day + sham surgery (sham). The primary endpoint was change in body weight gain from baseline to final. Secondary endpoints were uterine weight and cholesterol, triglyceride, glucose, and glucose/triglycerides index values at the end of the study. A modified intention-to-treat analysis was performed through linear regression models and using the Bonferroni method to penalized p-values by multiple comparisons. Results: Twenty-three animals completed the study. There was a significant average difference in weight gain, with a greater reduction in the S2 + OVX group compared to the OVX group (difference= −3.5; 95% CI (–5.27; −1.74); p <.001). S2 + OVX group also displayed a significant average reduction of total blood cholesterol (difference: −16.94; 95% CI (–33.73; −0.15); p =.037). No significant effects of the supplement were found on other secondary endpoints. Conclusion: In this murine menopausal model, triple oral supplement dose resulted in an average reduction of weight gain and total cholesterol levels, suggesting that the compound could have a potential effect at regulating menopausal altered metabolism. en_US
dc.language.iso eng
dc.publisher Taylor and Francis
dc.relation.ispartofseries Gynecological Endocrinology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Lepidium Meyenii en_US
dc.subject supplementation en_US
dc.subject glucosinolates en_US
dc.subject phytosterol en_US
dc.subject citrus flavonoids en_US
dc.subject menopause en_US
dc.subject body weight en_US
dc.subject metabolism en_US
dc.title Effect of a natural supplement containing glucosinolates, phytosterols and citrus flavonoids on body weight and metabolic parameters in a menopausal murine model induced by bilateral ovariectomy en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1080/09513590.2020.1821639
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.18
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.02
dc.relation.issn 1473-0766


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