Inflammatory pathway employed by Red Maca to treat induced benign prostatic hyperplasia in rats

Gonzales Rengifo, Gustavo Francisco; Gasco Tantachuco, Manuel Enrique; Fano Sizgorich, Diego Alejandro; Vásquez-Velásquez, C.

dc.contributor.author	Vásquez-Velásquez, C.
dc.contributor.author	Gasco Tantachuco, Manuel Enrique
dc.contributor.author	Fano Sizgorich, Diego Alejandro
dc.contributor.author	Gonzales Rengifo, Gustavo Francisco
dc.date.accessioned	2020-12-14T16:11:07Z
dc.date.available	2020-12-14T16:11:07Z
dc.date.issued	2020
dc.identifier.uri	https://hdl.handle.net/20.500.12866/8845
dc.description.abstract	Benign prostatic hyperplasia (BPH) is a pathology characterised by an increase in prostate size associated with low urinary tract symptoms. Finasteride (F), a 5a-reductase inhibitor, is the standard treatment for BPH reducing prostate weight but also sexual desire. The Peruvian plant known as Red Maca (RM) (Lepidium meyenii) inhibits BPH in rats and mice. The aim of the study was to assess the inflammatory effect of RM and finasteride in rats with testosterone enanthate (TE)-induced BPH. Thirty rats were divided into 5 groups: Control, TE (50 mg/rat), TE + F (0.6 mg/kg), and two groups of TE + RM 40/80 (40 or 80 mg). After treatments, tumour necrosis factor alpha (TNFa), interleukin 4 (IL4) and interferon gamma (INFg) as well as testosterone and oestradiol were evaluated and inflammatory cells (neutrophils, mast cells and lymphocytes) in prostate were quantified. Red Maca and finasteride treatments decreased inflammatory cells counts in prostate, inhibiting TNFa by different pathways. Finasteride increased IL4 whereas Red Maca increased INFg. In conclusion, data suggest that finasteride acts on Th2 response by increasing IL4 in prostate, while Red Maca acts on Th1 response mediated by INFg.	en_US
dc.language.iso	eng
dc.publisher	Wiley
dc.relation.ispartofseries	Andrologia
dc.rights	info:eu-repo/semantics/restrictedAccess
dc.subject	cytokines	en_US
dc.subject	inflammatory cells\|red maca	en_US
dc.subject	Th1	en_US
dc.subject	Th2	en_US
dc.title	Inflammatory pathway employed by Red Maca to treat induced benign prostatic hyperplasia in rats	en_US
dc.type	info:eu-repo/semantics/article
dc.identifier.doi	https://doi.org/10.1111/and.13516
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.02.01
dc.relation.issn	1439-0272