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Live births after oocyte in vitro maturation with a prematuration step in women with polycystic ovary syndrome

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dc.contributor.author Vuong, L.N.
dc.contributor.author Le, A.H.
dc.contributor.author Ho, V.N.A.
dc.contributor.author Pham, T.D.
dc.contributor.author Sanchez, Flor
dc.contributor.author Romero Loyola, Sergio Jean Markos
dc.contributor.author De Vos, M.
dc.contributor.author Ho, T.M.
dc.contributor.author Gilchrist, R.B.
dc.contributor.author Smitz, J.
dc.date.accessioned 2020-12-14T16:11:08Z
dc.date.available 2020-12-14T16:11:08Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8852
dc.description.abstract Purpose: Standard oocyte in vitro maturation (IVM) usually results in lower pregnancy rates than in vitro fertilization (IVF). IVM preceded by a prematuration step improves the acquisition of oocyte developmental competence and can enhance embryo quality (EQ). This study evaluated the effectiveness of a biphasic culture system incorporating prematuration and IVM steps (CAPA-IVM) versus standard IVM in women with polycystic ovarian morphology (PCOM). Methods: Eighty women (age < 38 years, ≥ 25 follicles of 2–9 mm in both ovaries, no major uterine abnormalities) were randomized to undergo CAPA-IVM (n = 40) or standard IVM (n = 40). CAPA-IVM uses two steps: a 24-h prematuration step with C-type natriuretic peptide-supplemented medium, then 30 h of culture in IVM media supplemented with follicle-stimulating hormone and amphiregulin. Standard IVM was performed using routine protocols. Results: A significantly higher proportion of oocytes reached metaphase II at 30 h after CAPA-IVM versus standard IVM (63.6 vs 49.0; p < 0.001) and the number of good quality embryos per cumulus-oocyte complex tended to be higher (18.9 vs 12.7; p = 0.11). Clinical pregnancy rate per embryo transfer was 63.2% in the CAPA-IVM versus 38.5% in the standard IVM group (p = 0.04). Live birth rate per embryo transfer was not statistically different between the CAPA-IVM and standard IVM groups (50.0 vs 33.3% [p = 0.17]). No malformations were reported and birth weight was similar in the two treatment groups. Conclusions: Use of the CAPA-IVM system significantly improved maturation and clinical pregnancy rates versus standard IVM in patients with PCOM. Furthermore, live births after CAPA-IVM are reported for the first time. en_US
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartofseries Journal of Assisted Reproduction and Genetics
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject In vitro fertilization en_US
dc.subject In vitro maturation en_US
dc.subject Polycystic ovary syndrome en_US
dc.subject Oocyte prematuration en_US
dc.subject C-type natriuretic peptide en_US
dc.title Live births after oocyte in vitro maturation with a prematuration step in women with polycystic ovary syndrome en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1007/s10815-019-01677-6
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.02
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.02
dc.relation.issn 1573-7330


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