Universidad Peruana Cayetano Heredia
Live births after oocyte in vitro maturation with a prematuration step in women with polycystic ovary syndrome
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| dc.contributor.author | Vuong, L.N. | |
| dc.contributor.author | Le, A.H. | |
| dc.contributor.author | Ho, V.N.A. | |
| dc.contributor.author | Pham, T.D. | |
| dc.contributor.author | Sanchez, Flor | |
| dc.contributor.author | Romero Loyola, Sergio Jean Markos | |
| dc.contributor.author | De Vos, M. | |
| dc.contributor.author | Ho, T.M. | |
| dc.contributor.author | Gilchrist, R.B. | |
| dc.contributor.author | Smitz, J. | |
| dc.date.accessioned | 2020-12-14T16:11:08Z | |
| dc.date.available | 2020-12-14T16:11:08Z | |
| dc.date.issued | 2020 | |
| dc.identifier.uri | https://hdl.handle.net/20.500.12866/8852 | |
| dc.description.abstract | Purpose: Standard oocyte in vitro maturation (IVM) usually results in lower pregnancy rates than in vitro fertilization (IVF). IVM preceded by a prematuration step improves the acquisition of oocyte developmental competence and can enhance embryo quality (EQ). This study evaluated the effectiveness of a biphasic culture system incorporating prematuration and IVM steps (CAPA-IVM) versus standard IVM in women with polycystic ovarian morphology (PCOM). Methods: Eighty women (age < 38 years, ≥ 25 follicles of 2–9 mm in both ovaries, no major uterine abnormalities) were randomized to undergo CAPA-IVM (n = 40) or standard IVM (n = 40). CAPA-IVM uses two steps: a 24-h prematuration step with C-type natriuretic peptide-supplemented medium, then 30 h of culture in IVM media supplemented with follicle-stimulating hormone and amphiregulin. Standard IVM was performed using routine protocols. Results: A significantly higher proportion of oocytes reached metaphase II at 30 h after CAPA-IVM versus standard IVM (63.6 vs 49.0; p < 0.001) and the number of good quality embryos per cumulus-oocyte complex tended to be higher (18.9 vs 12.7; p = 0.11). Clinical pregnancy rate per embryo transfer was 63.2% in the CAPA-IVM versus 38.5% in the standard IVM group (p = 0.04). Live birth rate per embryo transfer was not statistically different between the CAPA-IVM and standard IVM groups (50.0 vs 33.3% [p = 0.17]). No malformations were reported and birth weight was similar in the two treatment groups. Conclusions: Use of the CAPA-IVM system significantly improved maturation and clinical pregnancy rates versus standard IVM in patients with PCOM. Furthermore, live births after CAPA-IVM are reported for the first time. | en_US |
| dc.language.iso | eng | |
| dc.publisher | Springer | |
| dc.relation.ispartofseries | Journal of Assisted Reproduction and Genetics | |
| dc.rights | info:eu-repo/semantics/restrictedAccess | |
| dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
| dc.subject | In vitro fertilization | en_US |
| dc.subject | In vitro maturation | en_US |
| dc.subject | Polycystic ovary syndrome | en_US |
| dc.subject | Oocyte prematuration | en_US |
| dc.subject | C-type natriuretic peptide | en_US |
| dc.title | Live births after oocyte in vitro maturation with a prematuration step in women with polycystic ovary syndrome | en_US |
| dc.type | info:eu-repo/semantics/article | |
| dc.identifier.doi | https://doi.org/10.1007/s10815-019-01677-6 | |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.01.02 | |
| dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.02.02 | |
| dc.relation.issn | 1573-7330 |
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