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Prospective cohort study of influenza vaccine effectiveness among healthcare personnel in Lima, Peru: Estudio Vacuna de Influenza Peru, 2016-2018

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dc.contributor.author Wesley, M.G.
dc.contributor.author Soto, G.
dc.contributor.author Arriola, C.S.
dc.contributor.author Gonzales, M.
dc.contributor.author Newes-Adeyi, G.
dc.contributor.author Romero, Candice
dc.contributor.author Veguilla, V.
dc.contributor.author Levine, M.Z.
dc.contributor.author Silva, M.
dc.contributor.author Ferdinands, J.M.
dc.contributor.author Dawood, F.S.
dc.contributor.author Reynolds, S.B.
dc.contributor.author Hirsch, A.
dc.contributor.author Katz, M.
dc.contributor.author Matos, E.
dc.contributor.author Ticona, E.
dc.contributor.author Castro, J.
dc.contributor.author Castillo, M.
dc.contributor.author Bravo, E.
dc.contributor.author Cheung, A.
dc.contributor.author Phadnis, R.
dc.contributor.author Martin, E.T.
dc.contributor.author Tinoco, Y.
dc.contributor.author Neyra Quijandria, J.M.
dc.contributor.author Azziz-Baumgartner, E.
dc.contributor.author Thompson, M.G.
dc.contributor.author Sambhara, S.
dc.contributor.author Gangappa, S.
dc.contributor.author Malosh, R.E.
dc.contributor.author Flygare, C.
dc.contributor.author Cao, W.
dc.contributor.author Mishina, M.
dc.contributor.author Yoo, Y.M.
dc.contributor.author Mores, C.N.
dc.contributor.author Campbell, W.R.
dc.date.accessioned 2020-12-14T16:11:09Z
dc.date.available 2020-12-14T16:11:09Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/8854
dc.description.abstract Background: The Estudio Vacuna de Influenza Peru (VIP) cohort aims to describe the frequency of influenza virus infection, identify predictors of vaccine acceptance, examine the effects of repeated influenza vaccination on immunogenicity, and evaluate influenza vaccine effectiveness among HCP. Methods: The VIP cohort prospectively followed HCP in Lima, Peru, during the 2016-2018 influenza seasons; a fourth year is ongoing. Participants contribute blood samples before and after the influenza season and after influenza vaccination (for vaccinees). Weekly surveillance is conducted to identify acute respiratory or febrile illnesses (ARFI). When an ARFI is identified, participants self-collect nasal swabs that are tested for influenza viruses by real-time reverse transcriptase-polymerase chain reaction. Influenza vaccination status and 5-year vaccination history are ascertained. We analyzed recruitment and enrollment results for 2016-2018 and surveillance participation for 2016-2017. Results: In the first 3 years of the cohort, VIP successfully contacted 92% of potential participants, enrolled 76% of eligible HCP, and retained >90% of participants across years. About half of participants are medical assistants (54%), and most provide “hands-on” medical care (76%). Sixty-nine percent and 52% of participants completed surveillance for >70% of weeks in years 1 and 2, respectively. Fewer weeks of completed surveillance was associated with older age (≥50 years), being a medical assistant, self-rated health of fair or poor, and not receiving the influenza vaccine during the current season (P-values <.05). Conclusions: The VIP cohort provides an opportunity to address knowledge gaps about influenza virus infection, vaccination uptake, effectiveness and immunogenicity among HCP. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries Influenza and other Respiratory Viruses
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject healthcare personnel en_US
dc.subject influenza en_US
dc.subject influenza vaccine en_US
dc.title Prospective cohort study of influenza vaccine effectiveness among healthcare personnel in Lima, Peru: Estudio Vacuna de Influenza Peru, 2016-2018 en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1111/irv.12737
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.02
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.07
dc.relation.issn 1750-2659


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