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The 2018 Global Research Expedition on Altitude Related Chronic Health (Global REACH) to Cerro de Pasco, Peru: an Experimental Overview

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dc.contributor.author Tymko, Michael M.
dc.contributor.author Hoiland, Ryan L.
dc.contributor.author Tremblay, Joshua C.
dc.contributor.author Stembridge, Mike
dc.contributor.author Dawkins, Tony G.
dc.contributor.author Coombs, Geoff B.
dc.contributor.author Patrician, Alexander
dc.contributor.author Howe, Connor A.
dc.contributor.author Gibbons, Travis D.
dc.contributor.author Moore, Jonathan P.
dc.contributor.author Simpson, Lydia L.
dc.contributor.author Steinback, Craig D.
dc.contributor.author Meah, Victoria L.
dc.contributor.author Stacey, Benjamin S.
dc.contributor.author Bailey, Damian M.
dc.contributor.author MacLeod, David B.
dc.contributor.author Gasho, Christopher
dc.contributor.author Anholm, James D.
dc.contributor.author Bain, Anthony R.
dc.contributor.author Lawley, Justin S.
dc.contributor.author Villafuerte, Francisco C.
dc.contributor.author Vizcardo-Galindo, Gustavo
dc.contributor.author Ainslie, Philip N.
dc.date.accessioned 2021-04-13T20:50:57Z
dc.date.available 2021-04-13T20:50:57Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/9109
dc.description.abstract NEW FINDINGS: What is the central question of this study? Herein, a methodological overview of our research team's (Global REACH) latest high altitude research expedition to Peru is provided. What is the main finding and its importance? The experimental objectives, expedition organization, measurements and key cohort data are discussed. The select data presented in this manuscript demonstrate the haematological differences between lowlanders and Andeans with and without excessive erythrocytosis. The data also demonstrate that exercise capacity was similar between study groups at high altitude. The forthcoming findings from our research expedition will contribute to our understanding of lowlander and indigenous highlander high altitude adaptation. ABSTRACT: In 2016, the international research team Global Research Expedition on Altitude Related Chronic Health (Global REACH) was established and executed a high altitude research expedition to Nepal. The team consists of ∼45 students, principal investigators and physicians with the common objective of conducting experiments focused on high altitude adaptation in lowlanders and in highlanders with lifelong exposure to high altitude. In 2018, Global REACH travelled to Peru, where we performed a series of experiments in the Andean highlanders. The experimental objectives, organization and characteristics, and key cohort data from Global REACH's latest research expedition are outlined herein. Fifteen major studies are described that aimed to elucidate the physiological differences in high altitude acclimatization between lowlanders (n = 30) and Andean-born highlanders with (n = 22) and without (n = 45) excessive erythrocytosis. After baseline testing in Kelowna, BC, Canada (344 m), Global REACH travelled to Lima, Peru (∼80 m) and then ascended by automobile to Cerro de Pasco, Peru (∼4300 m), where experiments were conducted over 25 days. The core studies focused on elucidating the mechanism(s) governing cerebral and peripheral vascular function, cardiopulmonary regulation, exercise performance and autonomic control. Despite encountering serious logistical challenges, each of the proposed studies was completed at both sea level and high altitude, amounting to ∼780 study sessions and >3000 h of experimental testing. Participant demographics and data relating to acid-base balance and exercise capacity are presented. The collective findings will contribute to our understanding of how lowlanders and Andean highlanders have adapted under high altitude stress. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries Experimental Physiology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject adult en_US
dc.subject Article en_US
dc.subject controlled study en_US
dc.subject female en_US
dc.subject human en_US
dc.subject male en_US
dc.subject altitude acclimatization en_US
dc.subject altitude disease en_US
dc.subject Andean highlanders en_US
dc.subject autonomic nervous system en_US
dc.subject blood analysis en_US
dc.subject brain function en_US
dc.subject cardiopulmonary function en_US
dc.subject clinical research en_US
dc.subject cognition en_US
dc.subject cohort analysis en_US
dc.subject disease association en_US
dc.subject erythrocytosis en_US
dc.subject exercise en_US
dc.subject exercise test en_US
dc.subject geographic distribution en_US
dc.subject Global REACH en_US
dc.subject high altitude en_US
dc.subject hypobaric hypoxia en_US
dc.subject nitric oxide en_US
dc.subject oxidative stress en_US
dc.subject peripheral circulation en_US
dc.subject Peru en_US
dc.subject physician en_US
dc.subject physiological process en_US
dc.subject sea level en_US
dc.subject sleep time en_US
dc.subject transthoracic echocardiography en_US
dc.subject vein blood flow en_US
dc.title The 2018 Global Research Expedition on Altitude Related Chronic Health (Global REACH) to Cerro de Pasco, Peru: an Experimental Overview en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1113/EP088350
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.08
dc.relation.issn 1469-445X


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