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Effect of lepidium meyenii (Maca) on spatial memory and brain oxidative damage of ovariectomised-rats exposed to mobile phone

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dc.contributor.author Marín-Tello, C.
dc.contributor.author Villafana-Medina, H.
dc.contributor.author Malpartida-Tello, V.
dc.contributor.author Sánchez-Marín, C.
dc.contributor.author Castañeda-Marín, E.
dc.contributor.author Vásquez-Kool, J.
dc.contributor.author Aliaga-Arauco, J.
dc.date.accessioned 2021-04-13T20:50:58Z
dc.date.available 2021-04-13T20:50:58Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/9113
dc.description.abstract Background: Oxidative stress, genetic expression changes, and decomposition of the blood-brain barrier have been shown to be caused by exposure to radiofrequency radiation (RFR); therefore, the search for drugs or food products that offer some protection from these effects has attracted interest. Lepidium meyenii (maca) is a native Andean plant known for its effects on the female reproductive system as well as its immunomodulating, energizing, antioxidant, and nutritive properties due to its high concentration of alkaloids, amino acids, glucosinolates, fatty acids, and macamides. Objectives: We aim to determine the effect of dietary maca supplementation on spatial memory and cerebral oxidative damage in rats with induced menopause and/or with exposure to mobile phone radiation. Method: Female rats divided into 6 groups (six rats in each group): control or not ovariectomized (O-), ovariectomized (O+), ovariectomized + estrogen (O+E+), ovariectomized + estrogen + irradiated (O+E+I+), ovariectomized + maca (O+M+), and ovariectomized + maca + irradiated (O+M+I). Rat spatial memory was tested using the Morris water navigation task. Rats were sacrificed, and cerebral malondialdehyde was measured. Results: After exposure to mobile phone radiation, the group supplemented with maca showed improved spatial memory and lower levels of malondialdehyde than the estrogenized group. Conclusions: Our results suggest that consumption of maca has a positive effect on the maintenance of memory and decreases oxidative stress caused by mobile phone radiation. However, it is necessary to extend this work using a larger sample size. en_US
dc.language.iso eng
dc.publisher School of Pharmaceutical and Food Sciences, University of Antioquia
dc.relation.ispartofseries Vitae
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject adult en_US
dc.subject Article en_US
dc.subject female en_US
dc.subject male en_US
dc.subject cognition en_US
dc.subject oxidative stress en_US
dc.subject nonhuman en_US
dc.subject animal experiment en_US
dc.subject animal model en_US
dc.subject alkaloid en_US
dc.subject amino acid en_US
dc.subject animal tissue en_US
dc.subject antioxidant en_US
dc.subject blood brain barrier en_US
dc.subject brain en_US
dc.subject Cognition en_US
dc.subject decomposition en_US
dc.subject elevated plus maze test en_US
dc.subject essential oil en_US
dc.subject estradiol valerate en_US
dc.subject estrogen en_US
dc.subject Estrogens en_US
dc.subject evoked brain stem auditory response en_US
dc.subject fatty acid en_US
dc.subject female genital system en_US
dc.subject gene expression en_US
dc.subject glucosinolate en_US
dc.subject immunomodulation en_US
dc.subject Lepidium meyenii en_US
dc.subject Lepidium meyenii extract en_US
dc.subject lyophilisate en_US
dc.subject malonaldehyde en_US
dc.subject Malondialdehyde en_US
dc.subject memory en_US
dc.subject memory consolidation en_US
dc.subject menopause en_US
dc.subject Morris water maze test en_US
dc.subject nutrition en_US
dc.subject Nutrition en_US
dc.subject ovariectomy en_US
dc.subject Ovariectomy en_US
dc.subject passive avoidance test en_US
dc.subject plant extract en_US
dc.subject radiofrequency radiation en_US
dc.subject rat en_US
dc.subject spatial memory en_US
dc.subject superoxide dismutase en_US
dc.title Effect of lepidium meyenii (Maca) on spatial memory and brain oxidative damage of ovariectomised-rats exposed to mobile phone en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.17533/udea.vitae.v28n1a342472
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#4.04.01
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.05
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.01
dc.relation.issn 2145-2660


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