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Heterogeneity in response to serological exposure markers of recent Plasmodium vivax infections in contrasting epidemiological contexts

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dc.contributor.author Rosado, Jason
dc.contributor.author White, Michael T.
dc.contributor.author Longley, Rhea J.
dc.contributor.author Lacerda, Marcus
dc.contributor.author Monteiro, Wuelton
dc.contributor.author Brewster, Jessica
dc.contributor.author Sattabongkot, Jetsumon
dc.contributor.author Guzman Guzman, Mitchel Anthony
dc.contributor.author Llanos Cuentas, Elmer Alejandro
dc.contributor.author Vinetz, Joseph Michael
dc.contributor.author Gamboa Vilela, Dionicia Baziliza
dc.contributor.author Mueller, Ivo
dc.date.accessioned 2021-04-13T20:50:59Z
dc.date.available 2021-04-13T20:50:59Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/9132
dc.description.abstract BACKGROUND: Antibody responses as serological markers of Plasmodium vivax infection have been shown to correlate with exposure, but little is known about the other factors that affect antibody responses in naturally infected people from endemic settings. To address this question, we studied IgG responses to novel serological exposure markers (SEMs) of P. vivax in three settings with different transmission intensity. METHODOLOGY: We validated a panel of 34 SEMs in a Peruvian cohort with up to three years' longitudinal follow-up using a multiplex platform and compared results to data from cohorts in Thailand and Brazil. Linear regression models were used to characterize the association between antibody responses and age, the number of detected blood-stage infections during follow-up, and time since previous infection. Receiver Operating Characteristic (ROC) analysis was used to test the performance of SEMs to identify P. vivax infections in the previous 9 months. PRINCIPAL FINDINGS: Antibody titers were associated with age, the number of blood-stage infections, and time since previous P. vivax infection in all three study sites. The association between antibody titers and time since previous P. vivax infection was stronger in the low transmission settings of Thailand and Brazil compared to the higher transmission setting in Peru. Of the SEMs tested, antibody responses to RBP2b had the highest performance for classifying recent exposure in all sites, with area under the ROC curve (AUC) = 0.83 in Thailand, AUC = 0.79 in Brazil, and AUC = 0.68 in Peru. CONCLUSIONS: In low transmission settings, P. vivax SEMs can accurately identify individuals with recent blood-stage infections. In higher transmission settings, the accuracy of this approach diminishes substantially. We recommend using P. vivax SEMs in low transmission settings pursuing malaria elimination, but they are likely to be less effective in high transmission settings focused on malaria control. en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS Neglected Tropical Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Article en_US
dc.subject human en_US
dc.subject major clinical study en_US
dc.subject questionnaire en_US
dc.subject prevalence en_US
dc.subject risk factor en_US
dc.subject vaccination en_US
dc.subject enzyme linked immunosorbent assay en_US
dc.subject follow up en_US
dc.subject pregnancy en_US
dc.subject quality control en_US
dc.subject Plasmodium falciparum en_US
dc.subject antibody response en_US
dc.subject antibody titer en_US
dc.subject Ascaris lumbricoides en_US
dc.subject CD4+ T lymphocyte en_US
dc.subject discriminant analysis en_US
dc.subject dispersity en_US
dc.subject immunogenicity en_US
dc.subject immunoglobulin G en_US
dc.subject Plasmodium vivax en_US
dc.subject Plasmodium vivax malaria en_US
dc.subject receiver operating characteristic en_US
dc.subject sensitivity and specificity en_US
dc.subject serology en_US
dc.subject seroprevalence en_US
dc.title Heterogeneity in response to serological exposure markers of recent Plasmodium vivax infections in contrasting epidemiological contexts en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pntd.0009165
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1935-2735


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