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How natural selection shapes genetic differentiation in the MHC region: A case study with Native Americans

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dc.contributor.author Nunes, Kelly
dc.contributor.author Maia, Maria Helena Thomaz
dc.contributor.author Dos Santos, Eduardo José Melo
dc.contributor.author Dos Santos, Sidney Emanuel Batista
dc.contributor.author Guerreiro, João Farias
dc.contributor.author Petzl-Erler, Maria Luiza
dc.contributor.author Bedoya, Gabriel
dc.contributor.author Gallo López-Aliaga, Carla Maria
dc.contributor.author Poletti, Giovanni
dc.contributor.author Llop, Elena
dc.contributor.author Tsuneto, Luiza
dc.contributor.author Bortolini, Maria Cátira
dc.contributor.author Rothhammer, Francisco
dc.contributor.author Single, Richard
dc.contributor.author Ruiz-Linares, Andrés
dc.contributor.author Rocha, Jorge
dc.contributor.author Meyer, Diogo
dc.date.accessioned 2021-04-13T20:50:59Z
dc.date.available 2021-04-13T20:50:59Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/9137
dc.description.abstract The Human Leukocyte Antigen (HLA) loci are extremely well documented targets of balancing selection, yet few studies have explored how selection affects population differentiation at these loci. In the present study we investigate genetic differentiation at HLA genes by comparing differentiation at microsatellites distributed genomewide to those in the MHC region. Our study uses a sample of 494 individuals from 30 human populations, 28 of which are Native Americans, all of whom were typed for genomewide and MHC region microsatellites. We find greater differentiation in the MHC than in the remainder of the genome (F(ST-MHC) = 0.130 and F(ST-Genomic) = 0.087), and use a permutation approach to show that this difference is statistically significant, and not accounted for by confounding factors. This finding lies in the opposite direction to the expectation that balancing selection reduces population differentiation. We interpret our findings as evidence that selection favors different sets of alleles in distinct localities, leading to increased differentiation. Thus, balancing selection at HLA genes simultaneously increases intra-population polymorphism and inter-population differentiation in Native Americans. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Human Immunology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Balancing selection en_US
dc.subject HLA en_US
dc.subject MHC en_US
dc.subject Native Americans en_US
dc.subject Populational differentiation en_US
dc.title How natural selection shapes genetic differentiation in the MHC region: A case study with Native Americans en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.humimm.2021.03.005
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.03
dc.relation.issn 1879-1166


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