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Systemic lupus erythematosus: The search for the ideal biomarker

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dc.contributor.author González, Luis Alonso
dc.contributor.author Ugarte Gil, Manuel Francisco
dc.contributor.author Alarcón, Graciela S.
dc.date.accessioned 2021-04-13T20:51:00Z
dc.date.available 2021-04-13T20:51:00Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/9160
dc.description.abstract During the last decades, there has been an increased interest in the discovery and validation of biomarkers that reliably reflect specific aspects of lupus. Although many biomarkers have been developed, few of them have been validated and used in clinical practice, but with unsatisfactory performances. Thus, there is still a need to rigorously validate many of these novel promising biomarkers in large-scale longitudinal studies and also identify better biomarkers not only for lupus diagnosis but also for monitoring and predicting upcoming flares and response to treatment. Besides serological biomarkers, urinary and cerebrospinal fluid biomarkers have emerged for assessing both renal and central nervous system involvement in systemic lupus erythematosus, respectively. Also, novel omics techniques help us to understand the molecular basis of the disease and also allow the identification of novel biomarkers which may be potentially useful for guiding new therapeutic targets. en_US
dc.language.iso eng
dc.publisher SAGE Publications
dc.relation.ispartofseries Lupus
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject cytokine en_US
dc.subject Systemic lupus erythematosus en_US
dc.subject autoantibody en_US
dc.subject biomarkers en_US
dc.subject complement en_US
dc.subject interferon en_US
dc.title Systemic lupus erythematosus: The search for the ideal biomarker en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1177/0961203320979051
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.17
dc.relation.issn 1477-0962


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