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Global reach 2018: Influence of excessive erythrocytosis on coagulation and fibrinolytic factors in andean highlanders

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dc.contributor.author DeSouza, Noah M.
dc.contributor.author Brewster, L. Madden
dc.contributor.author Bain, Anthony R.
dc.contributor.author Garcia, Vinicius P.
dc.contributor.author Stone, Rachel
dc.contributor.author Stockelman, Kelly A.
dc.contributor.author Greiner, Jared J.
dc.contributor.author Tymko, Michael M.
dc.contributor.author Vizcardo-Galindo, Gustavo
dc.contributor.author Figueroa-Mujica, Romulo J.
dc.contributor.author Villafuerte, Francisco C.
dc.contributor.author Ainslie, Philip N.
dc.contributor.author DeSouza, Christopher A.
dc.date.accessioned 2021-04-13T20:51:01Z
dc.date.available 2021-04-13T20:51:01Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/9170
dc.description.abstract NEW FINDINGS: What is the central question of this study? Are coagulation and fibrinolytic factors disrupted in Andean highlanders with excessive excessive erythrocytosis. What is the main finding and its importance? Excessive erythrocytosis is not associated with prothombotic disruptions in coagulation or the fibrinolytic system in Andean highlanders. Impairments in coagulation and fibrinolysis may not contribute to the increased vascular risk associated with excessive erythrocytosis. ABSTRACT: Increased coagulation and reduced fibrinolysis are central factors underlying thrombotic risk and events. High altitude-induced excessive erythrocytosis (EE) is prevalent in Andean highlanders, contributing to increased cardiovascular risk. Disruption in the coagulation-fibrinolytic axis resulting in uncontrolled fibrin deposition may underlie the increased thrombotic risk associated with high altitude EE. The experimental aim of this study was to determine whether EE is associated with a prothrombotic blood coagulation and fibrinolytic profile in Andean highlanders. Plasma coagulation (von Willebrand factor {vWf}, factor VII, VIII, and X) and fibrinolytic (tissue-type plasminogen activator {t-PA} and plasminogen activator inhibitor-1 {PAI-1}) factors as well as D-dimer levels were determined in 26 male residents of Cerro de Pasco, Peru (4,340 m): 12 without EE (age: 40 ± 13 yr; Hb: 17.4 ± 1.9 g/dL) and 14 with EE (43 ± 15 yr; 24.4 ± 1.6 g/dL). There were no significant differences in vWf (40.5 ± 24.8 vs 45.5 ± 22.4 %), factor VII (77.0 ± 14.5 vs 72.5 ± 8.9 %), factor VIII (55.6 ± 19.8 vs 60.7 ± 26.8 %) and factor X (73.9 ± 8.3 vs 67.3 ± 10.9 %) between the Andean highlanders without or with EE. t-PA antigen (8.5 ± 3.6 vs 9.6 ± 5.4 ng/mL), t-PA activity (5.5 ± 2.4 vs 5.8 ± 1.6 IU/mL), PAI antigen (45.0 ± 33.8 vs 40.5 ± 15.8 ng/mL), PAI-1 activity (0.24 ± 0.09 vs 0.25 ± 0.11 IU/mL) and the molar concentration ratio of active t-PA to active PAI-1 (1:0.051 ± 0.034 vs 1:0.046 ± 0.021 mmol/L) were also similar between the groups as were D-dimer levels (235.0 ± 126.4 ng/mL vs 268.4 ± 173.7 ng/mL). Collectively, the results of present study indicate that EE is not associated with a hypercoagulable, hypofibrinolytic state in Andean highlanders. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries Experimental Physiology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject excessive erythrocytosis en_US
dc.subject coagulation en_US
dc.subject fibrinolysis en_US
dc.subject highlanders en_US
dc.title Global reach 2018: Influence of excessive erythrocytosis on coagulation and fibrinolytic factors in andean highlanders en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1113/EP089360
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.08
dc.relation.issn 1469-445X


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