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Household air pollution and blood markers of inflammation: A cross-sectional analysis

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dc.contributor.author Fandiño-Del-Rio, Magdalena
dc.contributor.author Kephart, Josiah L.
dc.contributor.author Williams, Kendra N.
dc.contributor.author Malpartida, Gary
dc.contributor.author Boyd Barr, Dana
dc.contributor.author Steenland, Kyle
dc.contributor.author Koehler, Kirsten
dc.contributor.author Checkley, William
dc.date.accessioned 2021-04-13T20:51:01Z
dc.date.available 2021-04-13T20:51:01Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/9179
dc.description.abstract Household air pollution (HAP) from biomass stoves is a leading risk factor for cardiopulmonary outcomes; however, its toxicity pathways and relationship with inflammation markers are poorly understood. Among 180 adult women in rural Peru, we examined the cross-sectional exposure-response relationship between biomass HAP and markers of inflammation in blood using baseline measurements from a randomized trial. We measured markers of inflammation (CRP, IL-6, IL-10, IL-1β, and TNF-α) with dried blood spots, 48-h kitchen area concentrations and personal exposures to fine particulate matter (PM(2.5) ), black carbon (BC), and carbon monoxide (CO), and 48-h kitchen concentrations of nitrogen dioxide (NO(2) ) in a subset of 97 participants. We conducted an exposure-response analysis between quintiles of HAP levels and markers of inflammation. Markers of inflammation were more strongly associated with kitchen area concentrations of BC than PM(2.5) . As expected, kitchen area BC concentrations were positively associated with TNF-α (pro-inflammatory) concentrations and negatively associated with IL-10, an anti-inflammatory marker, controlling for confounders in single- and multi-pollutant models. However, contrary to expectations, kitchen area BC and NO(2) concentrations were negatively associated with IL-1β, a pro-inflammatory marker. No associations were identified for IL-6 or CRP, or for any marker in relation to personal exposures. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries Indoor Air
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject household air pollution en_US
dc.subject fine particulate matter en_US
dc.subject biomass stoves en_US
dc.subject black carbon en_US
dc.subject exposure-response en_US
dc.subject markers of inflammation en_US
dc.title Household air pollution and blood markers of inflammation: A cross-sectional analysis en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1111/ina.12814
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#2.01.03
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.05
dc.relation.issn 1600-0668


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