dc.contributor.author |
Fandiño-Del-Rio, Magdalena |
|
dc.contributor.author |
Kephart, Josiah L. |
|
dc.contributor.author |
Williams, Kendra N. |
|
dc.contributor.author |
Malpartida, Gary |
|
dc.contributor.author |
Boyd Barr, Dana |
|
dc.contributor.author |
Steenland, Kyle |
|
dc.contributor.author |
Koehler, Kirsten |
|
dc.contributor.author |
Checkley, William |
|
dc.date.accessioned |
2021-04-13T20:51:01Z |
|
dc.date.available |
2021-04-13T20:51:01Z |
|
dc.date.issued |
2021 |
|
dc.identifier.uri |
https://hdl.handle.net/20.500.12866/9179 |
|
dc.description.abstract |
Household air pollution (HAP) from biomass stoves is a leading risk factor for cardiopulmonary outcomes; however, its toxicity pathways and relationship with inflammation markers are poorly understood. Among 180 adult women in rural Peru, we examined the cross-sectional exposure-response relationship between biomass HAP and markers of inflammation in blood using baseline measurements from a randomized trial. We measured markers of inflammation (CRP, IL-6, IL-10, IL-1β, and TNF-α) with dried blood spots, 48-h kitchen area concentrations and personal exposures to fine particulate matter (PM(2.5) ), black carbon (BC), and carbon monoxide (CO), and 48-h kitchen concentrations of nitrogen dioxide (NO(2) ) in a subset of 97 participants. We conducted an exposure-response analysis between quintiles of HAP levels and markers of inflammation. Markers of inflammation were more strongly associated with kitchen area concentrations of BC than PM(2.5) . As expected, kitchen area BC concentrations were positively associated with TNF-α (pro-inflammatory) concentrations and negatively associated with IL-10, an anti-inflammatory marker, controlling for confounders in single- and multi-pollutant models. However, contrary to expectations, kitchen area BC and NO(2) concentrations were negatively associated with IL-1β, a pro-inflammatory marker. No associations were identified for IL-6 or CRP, or for any marker in relation to personal exposures. |
en_US |
dc.language.iso |
eng |
|
dc.publisher |
Wiley |
|
dc.relation.ispartofseries |
Indoor Air |
|
dc.rights |
info:eu-repo/semantics/restrictedAccess |
|
dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
|
dc.subject |
household air pollution |
en_US |
dc.subject |
fine particulate matter |
en_US |
dc.subject |
biomass stoves |
en_US |
dc.subject |
black carbon |
en_US |
dc.subject |
exposure-response |
en_US |
dc.subject |
markers of inflammation |
en_US |
dc.title |
Household air pollution and blood markers of inflammation: A cross-sectional analysis |
en_US |
dc.type |
info:eu-repo/semantics/article |
|
dc.identifier.doi |
https://doi.org/10.1111/ina.12814 |
|
dc.subject.ocde |
https://purl.org/pe-repo/ocde/ford#2.01.03 |
|
dc.subject.ocde |
https://purl.org/pe-repo/ocde/ford#3.03.05 |
|
dc.relation.issn |
1600-0668 |
|