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dc.contributor.author | Fandiño-Del-Rio, Magdalena | |
dc.contributor.author | Kephart, Josiah L. | |
dc.contributor.author | Williams, Kendra N. | |
dc.contributor.author | Malpartida, Gary | |
dc.contributor.author | Boyd Barr, Dana | |
dc.contributor.author | Steenland, Kyle | |
dc.contributor.author | Koehler, Kirsten | |
dc.contributor.author | Checkley, William | |
dc.date.accessioned | 2021-04-13T20:51:01Z | |
dc.date.available | 2021-04-13T20:51:01Z | |
dc.date.issued | 2021 | |
dc.identifier.uri | https://hdl.handle.net/20.500.12866/9179 | |
dc.description.abstract | Household air pollution (HAP) from biomass stoves is a leading risk factor for cardiopulmonary outcomes; however, its toxicity pathways and relationship with inflammation markers are poorly understood. Among 180 adult women in rural Peru, we examined the cross-sectional exposure-response relationship between biomass HAP and markers of inflammation in blood using baseline measurements from a randomized trial. We measured markers of inflammation (CRP, IL-6, IL-10, IL-1β, and TNF-α) with dried blood spots, 48-h kitchen area concentrations and personal exposures to fine particulate matter (PM(2.5) ), black carbon (BC), and carbon monoxide (CO), and 48-h kitchen concentrations of nitrogen dioxide (NO(2) ) in a subset of 97 participants. We conducted an exposure-response analysis between quintiles of HAP levels and markers of inflammation. Markers of inflammation were more strongly associated with kitchen area concentrations of BC than PM(2.5) . As expected, kitchen area BC concentrations were positively associated with TNF-α (pro-inflammatory) concentrations and negatively associated with IL-10, an anti-inflammatory marker, controlling for confounders in single- and multi-pollutant models. However, contrary to expectations, kitchen area BC and NO(2) concentrations were negatively associated with IL-1β, a pro-inflammatory marker. No associations were identified for IL-6 or CRP, or for any marker in relation to personal exposures. | en_US |
dc.language.iso | eng | |
dc.publisher | Wiley | |
dc.relation.ispartofseries | Indoor Air | |
dc.rights | info:eu-repo/semantics/restrictedAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es | |
dc.subject | household air pollution | en_US |
dc.subject | fine particulate matter | en_US |
dc.subject | biomass stoves | en_US |
dc.subject | black carbon | en_US |
dc.subject | exposure-response | en_US |
dc.subject | markers of inflammation | en_US |
dc.title | Household air pollution and blood markers of inflammation: A cross-sectional analysis | en_US |
dc.type | info:eu-repo/semantics/article | |
dc.identifier.doi | https://doi.org/10.1111/ina.12814 | |
dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#2.01.03 | |
dc.subject.ocde | https://purl.org/pe-repo/ocde/ford#3.03.05 | |
dc.relation.issn | 1600-0668 |
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