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Hypoxia-induced pulmonary hypertension—Utilizing experiments of nature

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dc.contributor.author Gassmann, M.
dc.contributor.author Cowburn, A.
dc.contributor.author Gu, H.
dc.contributor.author Li, J.
dc.contributor.author Rodriguez, Marisela
dc.contributor.author Babicheva, A.
dc.contributor.author Jain, P.P.
dc.contributor.author Xiong, M.
dc.contributor.author Gassmann, N.N.
dc.contributor.author Yuan, J.X.J.
dc.contributor.author Wilkins, M.R.
dc.contributor.author Zhao, L.
dc.date.accessioned 2021-04-13T20:51:01Z
dc.date.available 2021-04-13T20:51:01Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/9183
dc.description.abstract An increase in pulmonary artery pressure is a common observation in adult mammals exposed to global alveolar hypoxia. It is considered a maladaptive response that places an increased workload on the right ventricle. The mechanisms initiating and maintaining the elevated pressure are of considerable interest in understanding pulmonary vascular homeostasis. There is an expectation that identifying the key molecules in the integrated vascular response to hypoxia will inform potential drug targets. One strategy is to take advantage of experiments of nature, specifically, to understand the genetic basis for the inter-individual variation in the pulmonary vascular response to acute and chronic hypoxia. To date, detailed phenotyping of highlanders has focused on haematocrit and oxygen saturation rather than cardiovascular phenotypes. This review explores what we can learn from those studies with respect to the pulmonary circulation. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries British Journal of Dermatology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject human en_US
dc.subject priority journal en_US
dc.subject genetics en_US
dc.subject altitude en_US
dc.subject arterial smooth muscle cell en_US
dc.subject E1A associated p300 protein en_US
dc.subject endothelin en_US
dc.subject gene identification en_US
dc.subject genetic analysis en_US
dc.subject hematocrit en_US
dc.subject high-altitude en_US
dc.subject homeostasis en_US
dc.subject hypoxia inducible factor en_US
dc.subject hypoxia inducible factor 1alpha en_US
dc.subject hypoxia inducible factor 2alpha en_US
dc.subject hypoxia inducible factor 3alpha en_US
dc.subject hypoxia-induced pulmonary hypertension en_US
dc.subject hypoxia-inducible factor en_US
dc.subject hypoxiainducible factor prolyl hydroxylase 2 en_US
dc.subject interleukin 6 en_US
dc.subject lung artery pressure en_US
dc.subject lung hemodynamics en_US
dc.subject nonhuman en_US
dc.subject oxygen saturation en_US
dc.subject oxygen sensing en_US
dc.subject platelet derived growth factor en_US
dc.subject protein function en_US
dc.subject pulmonary vasoconstriction en_US
dc.subject Review en_US
dc.subject sequence analysis en_US
dc.subject signal transduction en_US
dc.subject vascular remodeling en_US
dc.subject vascular remodelling en_US
dc.title Hypoxia-induced pulmonary hypertension—Utilizing experiments of nature en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.1111/bph.15144
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.15
dc.relation.issn 1365-2133


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