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PvMSP8 as a Novel Plasmodium vivax Malaria Sero-Marker for the Peruvian Amazon

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dc.contributor.author Villasis Mayuri, Elizabeth Melisa
dc.contributor.author Garro, Katherine
dc.contributor.author Rosas-Aguirre, Ángel
dc.contributor.author Rodríguez, Pamela
dc.contributor.author Rosado, Jason
dc.contributor.author Gave, Anthony
dc.contributor.author Guzman Guzman, Mitchel Anthony
dc.contributor.author Manrique Valverde, Paulo Cesar
dc.contributor.author White, Michael
dc.contributor.author Speybroeck, Niko
dc.contributor.author Vinetz, Joseph Michael
dc.contributor.author Torres Fajardo, Katherine Jessica
dc.contributor.author Gamboa Vilela, Dionicia Baziliza
dc.date.accessioned 2021-04-13T20:51:02Z
dc.date.available 2021-04-13T20:51:02Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/9206
dc.description.abstract The measurement of recent malaria exposure can support malaria control efforts. This study evaluated serological responses to an in-house Plasmodium vivax Merozoite Surface Protein 8 (PvMSP8) expressed in a Baculovirus system as sero-marker of recent exposure to P. vivax (Pv) in the Peruvian Amazon. In a first evaluation, IgGs against PvMSP8 and PvMSP10 proteins were measured by Luminex in a cohort of 422 Amazonian individuals with known history of Pv exposure (monthly data of infection status by qPCR and/or microscopy over five months). Both serological responses were able to discriminate between exposed and non-exposed individuals in a good manner, with slightly higher performance of anti-PvMSP10 IgGs (area under the curve AUC = 0.78 [95% CI = 0.72-0.83]) than anti-PvMSP8 IgGs (AUC = 0.72 [95% CI = 0.67-0.78]) (p = 0.01). In a second evaluation, the analysis by ELISA of 1251 plasma samples, collected during a population-based cross-sectional survey, confirmed the good performance of anti-PvMSP8 IgGs for discriminating between individuals with Pv infection at the time of survey and/or with antecedent of Pv in the past month (AUC = 0.79 [95% CI = 0.74-0.83]). Anti-PvMSP8 IgG antibodies can be considered as a good biomarker of recent Pv exposure in low-moderate transmission settings of the Peruvian Amazon. en_US
dc.description.sponsorship Este trabajo fue parcialmente financiado por el Proyecto CONCYTEC-Banco Mundial “Mejoramiento y Ampliación de Servicios del Sistema Nacional de Ciencia, Tecnología e Innovación Tecnológica” 8682-PE, a través de su unidad ejecutora FONDECYT [número de contrato 08-2018-E033- FONDECYT-BM-Programas de Doctorado en Áreas Estratégicas y Generales]. es_PE
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartofseries Pathogens
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject malaria en_US
dc.subject Malaria en_US
dc.subject Antibodies en_US
dc.subject ELISA en_US
dc.subject Luminex en_US
dc.subject P. vivax en_US
dc.subject PvMSP8 en_US
dc.subject antibodies en_US
dc.title PvMSP8 as a Novel Plasmodium vivax Malaria Sero-Marker for the Peruvian Amazon en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.3390/pathogens10030282
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.09
dc.relation.issn 2076-0817


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