Universidad Peruana Cayetano Heredia

Antiretroviral therapy and Kaposi's sarcoma trends and outcomes among adults with HIV in Latin America

Mostrar el registro sencillo del ítem

dc.contributor.author Castilho, Jessica L.
dc.contributor.author Kim, Ahra
dc.contributor.author Jenkins, Cathy A.
dc.contributor.author Grinsztejn, Beatriz
dc.contributor.author Gotuzzo Herencia, José Eduardo
dc.contributor.author Fink, Valeria
dc.contributor.author Padgett, Denis
dc.contributor.author Belaunzaran Zamudio, Pablo F.
dc.contributor.author Crabtree Ramírez, Brenda
dc.contributor.author Escuder, Maria Mercedes
dc.contributor.author Alencar Souza, Rosa
dc.contributor.author Tenore, Simone B.
dc.contributor.author Pimentel, Sidnei R.
dc.contributor.author Rodrigues Ikeda, Maria Letícia
dc.contributor.author de Alencastro, Paulo R.
dc.contributor.author Tupinanbas, Unai
dc.contributor.author Brites, Carlos
dc.contributor.author Luz, Estela
dc.contributor.author Netto, Juliana
dc.contributor.author Cortes, Claudia P.
dc.contributor.author Grangeiro, Alexandre
dc.contributor.author Shepherd, Bryan E.
dc.contributor.author McGowan, Catherine C.
dc.date.accessioned 2021-04-13T20:51:03Z
dc.date.available 2021-04-13T20:51:03Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/9210
dc.description.abstract INTRODUCTION: Kaposi's sarcoma (KS) remains the most frequent malignancy in persons living with HIV (PWH) in Latin America. We examined KS trends and outcomes from Latin American clinical sites in the era of increased access to antiretroviral therapy (ART). METHODS: Cohorts in Brazil, Peru, Mexico, Honduras, Argentina and Chile contributed clinical data of PWH ≥16 years old from 2000 to 2017, excluding patients with KS diagnosed before clinic enrolment. We compared KS incidence over time using multivariable incidence rate ratios. Predictors of KS before/at or after ART initiation and of mortality after KS were examined using Cox regression. RESULTS: Of 25 981 PWH, 481 had incident KS, including 200 ART-naïve and 281 ART-treated patients. From 2000 to 2017, the incidence of KS decreased from 55.1 to 3.0 per 1000 person-years. In models adjusting for CD4 and other factors, the relative risk for KS decreased from 2000 to 2008. Since 2010, the adjusted risk of KS increased in the periods before and ≤90 days after ART initiation but decreased >90 days after ART. In addition to low CD4 and male-to-male sex, KS risk after ART was associated with age and history of other AIDS-defining illnesses. Mortality after KS (approximately 25% after five years) was not associated with either year of KS diagnosis nor timing of diagnosis relative to ART initiation. CONCLUSIONS: KS incidence in Latin America has remained stable in recent years and risk is highest before and shortly after ART initiation. Early diagnosis of HIV and ART initiation remain critical priorities in the region. en_US
dc.language.iso eng
dc.publisher Wiley
dc.relation.ispartofseries Journal of the International AIDS Society
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject mortality en_US
dc.subject Latin America en_US
dc.subject HIV en_US
dc.subject incidence en_US
dc.subject antiretroviral therapy en_US
dc.subject Kaposi’s sarcoma en_US
dc.title Antiretroviral therapy and Kaposi's sarcoma trends and outcomes among adults with HIV in Latin America en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1002/jia2.25658
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 1758-2652


Ficheros en el ítem

Ficheros Tamaño Formato Ver

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

info:eu-repo/semantics/restrictedAccess Excepto si se señala otra cosa, la licencia del ítem se describe como info:eu-repo/semantics/restrictedAccess

Buscar en el Repositorio


Listar

Panel de Control

Estadísticas