Universidad Peruana Cayetano Heredia

Screening for human t-cell lymphotropic virus (Htlv) in pregnant women in the peruvian amazon and systematic review with meta-analysis of htlv infection in Peru

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dc.contributor.author Ramos-Rincón, J.-M.
dc.contributor.author Ortiz-Martínez, S.
dc.contributor.author Vásquez-Chasnamote, M.-E.
dc.contributor.author De-Miguel-Balsa, E.
dc.contributor.author Gamboa-Paredes, O.-N.
dc.contributor.author Talledo Albujar, Michael John
dc.contributor.author López-Campana, G.
dc.contributor.author Celis-Salinas, J.C.
dc.contributor.author Prieto-Pérez, L.
dc.contributor.author Górgolas-Hernández, M.
dc.contributor.author Casapía-Morales, M.
dc.date.accessioned 2021-04-13T20:51:03Z
dc.date.available 2021-04-13T20:51:03Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/9215
dc.description.abstract Background. Human T-cell lymphotropic virus type 1 (HTLV-1) is responsible for tropical spastic paraparesis and HTLV-1-associated leukemia/lymphoma. The infection is endemic in some areas of Peru, but its prevalence in the Peruvian Amazon is not well established. We aimed to assess the seroprevalence of HTLV-1 infection in pregnant women in the Peruvian Amazon. Moreover, we performed a systematic literature review and meta-analysis of the seroprevalence of HTLV infection in Peru. (2) Methods. This is a prospective cross-sectional study involving pregnant women attending health centers in the city of Iquitos, Peru, in May and June 2019. The presence of antibodies against HTLV-1 was assessed using ELISA (HTLV I + II ELISA recombinant v.4.0, Wiener lab, Rosario, Argentina). Positive cases were confirmed by Western Blot and HTLV-1 proviral load. (3) Results. The study included 300 pregnant women with a mean age of 26 years (standard deviation [SD] 6.4). Five patients were diagnosed with HTLV-1 infection (prevalence 1.7%, 95% confidence interval (CI) 0.7% to 3.8%). Pregnant women with HTLV-1 infection were discretely younger (mean age 22.6 [SD 22.6] vs 26.8 [SD 6.3]; p = 0.128). None of the five women had been transfused, and all were asymptomatic. Two (40%) also had a positive serology for Strongy-loides, but larvae were not detected in any of the parasitological stool studies. The systematic review component identified 40 studies, which showed that the prevalence of HTLV infection in the general population was 2.9% (95% CI 1.2% to 5.3%) and in women of childbearing age, 2.5% (95% CI 1.2% to 4.0%). (4) Conclusion. The prevalence of HTLV-1 in the Peruvian Amazon basin is about 1.7%, indicating an endemic presence. Screening for HTLV-1 in prenatal care is warranted. en_US
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartofseries Pathogens
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Peru en_US
dc.subject Amazon en_US
dc.subject HTLV en_US
dc.subject Pregnant women en_US
dc.subject Prevalence en_US
dc.subject Systematic review en_US
dc.title Screening for human t-cell lymphotropic virus (Htlv) in pregnant women in the peruvian amazon and systematic review with meta-analysis of htlv infection in Peru en_US
dc.type info:eu-repo/semantics/review
dc.identifier.doi https://doi.org/10.3390/pathogens10030260
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.09
dc.relation.issn 2076-0817


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