Universidad Peruana Cayetano Heredia

Market Chickens as a Source of Antibiotic-Resistant Escherichia coli in a Peri-Urban Community in Lima, Peru

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dc.contributor.author Murray, Matthew
dc.contributor.author Salvatierra, Guillermo
dc.contributor.author Dávila-Barclay, Alejandra
dc.contributor.author Ayzanoa, Brenda
dc.contributor.author Castillo-Vilcahuaman, Camila
dc.contributor.author Huang, Michelle
dc.contributor.author Pajuelo Travezaño, Monica Jhenny
dc.contributor.author Lescano Guevara, Andres Guillermo
dc.contributor.author Cabrera, Lilia
dc.contributor.author Calderón Sánchez, Maritza Mercedes
dc.contributor.author Berg, Douglas E.
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author Tsukayama Cisneros, Pablo
dc.date.accessioned 2021-04-13T20:51:03Z
dc.date.available 2021-04-13T20:51:03Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/9219
dc.description.abstract The widespread and poorly regulated use of antibiotics in animal production in low- and middle-income countries (LMICs) is increasingly associated with the emergence and dissemination of antibiotic resistance genes (ARGs) in retail animal products. Here, we compared Escherichia coli from chickens and humans with varying levels of exposure to chicken meat in a low-income community in the southern outskirts of Lima, Peru. We hypothesize that current practices in local poultry production result in highly resistant commensal bacteria in chickens that can potentially colonize the human gut. E. coli was isolated from cloacal swabs of non-organic (n = 41) and organic chickens (n = 20), as well as from stools of market chicken vendors (n = 23), non-vendors (n = 48), and babies (n = 60). 315 E. coli isolates from humans (n = 150) and chickens (n = 165) were identified, with chickens showing higher rates of multidrug-resistant and extended-spectrum beta-lactamase phenotypes. Non-organic chicken isolates were more resistant to most antibiotics tested than human isolates, while organic chicken isolates were susceptible to most antibiotics. Whole-genome sequencing of 118 isolates identified shared phylogroups between human and animal populations and 604 ARG hits across genomes. Resistance to florfenicol (an antibiotic commonly used as a growth promoter in poultry but not approved for human use) was higher in chicken vendors compared to other human groups. Isolates from non-organic chickens contained genes conferring resistance to clinically relevant antibiotics, including mcr-1 for colistin resistance, blaCTX-M ESBLs, and blaKPC-3 carbapenemase. Our findings suggest that E. coli strains from market chickens are a potential source of ARGs that can be transmitted to human commensals. en_US
dc.language.iso eng
dc.publisher Frontiers Media
dc.relation.ispartofseries Frontiers in Microbiology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Peru en_US
dc.subject Escherichia coli en_US
dc.subject genomics en_US
dc.subject AMR en_US
dc.subject LMIC en_US
dc.subject one health en_US
dc.subject poultry en_US
dc.subject WGS en_US
dc.title Market Chickens as a Source of Antibiotic-Resistant Escherichia coli in a Peri-Urban Community in Lima, Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.3389/fmicb.2021.635871
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.01
dc.relation.issn 1664-302X


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