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Towards one standard treatment for uncomplicated Plasmodium falciparum and Plasmodium vivax malaria: Perspectives from and for the Peruvian Amazon

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dc.contributor.author Fernández-Miñope, Carlos
dc.contributor.author Delgado Ratto, Christopher
dc.contributor.author Contreras-Mancilla, Juan
dc.contributor.author Rodríguez Ferrucci, Hugo
dc.contributor.author Llanos Cuentas, Elmer Alejandro
dc.contributor.author Gamboa Vilela, Dionicia Baziliza
dc.contributor.author Van Geertruyden, Jean-Pierre
dc.date.accessioned 2021-04-13T20:51:03Z
dc.date.available 2021-04-13T20:51:03Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/9220
dc.description.abstract Malaria continues to wreak havoc in the Peruvian Amazon. Lengthy research efforts have brought important lessons on its particular epidemiology: the heterogeneous levels of transmission, the large reservoir of both asymptomatic and submicroscopic infections, the co-transmission of Plasmodium vivax and Plasmodium falciparum in the same areas, and the limitations of current diagnostics. Based on these features, the national elimination program could greatly benefit from simplified standard treatment, with the use of artemisinin-based combination therapy and even shorter schemes of primaquine maintaing the total dosing. It is acknowledged that there is some uncertainty regarding the true prevalence of glucose-6-phosphate dehydrogenase deficiency (G6PD) and genetic polymorphisms related to cytochrome P-450 isozyme 2D6 functioning. Once we have a better understanding, tafenoquine, whether or not in combination with a rapid G6PD enzyme test, may become a future pathway to eliminate the otherwise hidden reservoir of the P. vivax hypnozoite through one standard Plasmodium treatment. en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries International Journal of Infectious Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Peru en_US
dc.subject Treatment en_US
dc.subject South America en_US
dc.subject Plasmodium vivax en_US
dc.subject Plasmodium falciparum en_US
dc.subject Control en_US
dc.subject Elimination en_US
dc.subject Policy en_US
dc.title Towards one standard treatment for uncomplicated Plasmodium falciparum and Plasmodium vivax malaria: Perspectives from and for the Peruvian Amazon en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.ijid.2021.02.042
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.relation.issn 1878-3511


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