Universidad Peruana Cayetano Heredia

Effect of bovine lactoferrin on prevention of late-onset sepsis in infants <1500 g: a pooled analysis of individual patient data from two randomized controlled trials

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dc.contributor.author Ochoa Woodell, Theresa Jean
dc.contributor.author Loli, Sebastián
dc.contributor.author Mendoza, Karina
dc.contributor.author Cárcamo Cavagnaro, César Paul Eugenio
dc.contributor.author Bellomo, Sicilia
dc.contributor.author Cam, Luis
dc.contributor.author Castañeda, Anne
dc.contributor.author Campos, Miguel
dc.contributor.author Jacobs, Jan
dc.contributor.author Cossey, Veerle
dc.contributor.author Zegarra, Jaime
dc.date.accessioned 2021-04-13T20:51:03Z
dc.date.available 2021-04-13T20:51:03Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/9222
dc.description.abstract We previously conducted two randomized controlled trials with bovine lactoferrin (bLF) for the prevention of lateonset sepsis (LOS) in infants with a birth weight <2500 g (Study 1) and <2000 g (Study 2). The aim of this study was to determine the preventative effects of bLF on culture-proven or probable LOS in infants with a birth weight <1500 g from both studies, and to determine the effect of bLF in relation to intake of human milk. Both trial designs had similar inclusion and exclusion criteria, the same dose of bLF [200 mg.(kg body mass)(-1).day(-1)], and used the same control (maltodextrin). We fitted multivariate Cox regression models to estimate the effect of bLF on the risk of development of the composite outcome, adjusting for covariates. We included 335 neonates with a mean birth weight of 1162 6 244 g; 27.5% were <1000 g. There were 33 first episodes of LOS in the bLF treatment group and 48 in the control group (19.5% vs. 28.9%). bLF had a protective effect on the risk of development of LOS [hazard ratio (HR) = 0.64; %95 CI = 0.41-0.99; p = 0.048]; particularly among infants weighing <1000 g [HR = 0.46; %95 CI = 0.22-0.96; p = 0.039] and infants with a low intake of human milk [HR = 0.40; %95 CI = 0.19-0.84; p = 0.015]. Therefore, bLF supplementation protects infants <1500 g from LOS, particularly those infants not receiving human milk. en_US
dc.language.iso eng
dc.publisher NRC Research Press
dc.relation.ispartofseries Biochemistry and Cell Biology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject randomized controlled trial en_US
dc.subject Bovine lactoferrin en_US
dc.subject Dairies en_US
dc.subject First episodes en_US
dc.subject Hospital data processing en_US
dc.subject Inclusion and exclusions en_US
dc.subject Individual patient data en_US
dc.subject Lactoferrin en_US
dc.subject Mammals en_US
dc.subject Neonatal en_US
dc.subject Preventative effect en_US
dc.subject Protective effects en_US
dc.subject Randomized controlled trial en_US
dc.subject Regression analysis en_US
dc.subject Risk perception en_US
dc.subject Sepsis en_US
dc.subject Treatment group en_US
dc.subject essai contrôlé randomisé en_US
dc.subject lactoferrin en_US
dc.subject lactoferrine en_US
dc.subject neonatal en_US
dc.subject néonatal en_US
dc.subject sepsis en_US
dc.subject septicémie en_US
dc.title Effect of bovine lactoferrin on prevention of late-onset sepsis in infants <1500 g: a pooled analysis of individual patient data from two randomized controlled trials en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1139/bcb-2020-0046
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.03
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.01
dc.relation.issn 1208-6002


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