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Total Urinary Arsenic and Inorganic Arsenic Concentrations and Birth Outcomes in Pregnant Women of Tacna, Peru: A Cross-Sectional Study

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dc.contributor.author Fano Sizgorich, Diego Alejandro
dc.contributor.author Vásquez Velásquez, Cinthya
dc.contributor.author Yucra, Sandra
dc.contributor.author Vasquez Apéstegui, Bertha Vanessa
dc.contributor.author Tokeshi, Patricio
dc.contributor.author Aguilar, Julio
dc.contributor.author Ramírez Atencio, Claudio
dc.contributor.author Barr, Dana
dc.contributor.author Gonzales Rengifo, Gustavo Francisco
dc.date.accessioned 2021-04-13T20:51:05Z
dc.date.available 2021-04-13T20:51:05Z
dc.date.issued 2020
dc.identifier.uri https://hdl.handle.net/20.500.12866/9253
dc.description.abstract Inorganic arsenic exposure has been linked to the development of several health conditions, including adverse birth outcomes; and around 150 million of people worldwide are exposed to levels above the WHO suggested limit of 10 μg/L. A recent risk assessment in pregnant women of Tacna, of this same population performed by our group, found that 70.25% were exposed to arsenic concentrations in drinking water ≥25 μg/L. The present study aimed to evaluate the relationship between prenatal total urinary arsenic (U-tAs) and inorganic arsenic (U-iAs) with adverse birth outcomes. A total of 147 pregnant women from the province of Tacna, Peru, during February - March, 2019, were evaluated for U-tAs and U-iAs exposure during their second trimester of pregnancy, while the birth records of their children were collected from the local hospital. The geometric mean U-tAs was 43.97 ± 25.88 μg/L (P(50) 22.30, range 5.99 - 181.94 μg/L) and U-iAs was 5.27 ± 2.91 μg/L. Controlling for maternal age, pre-pregnancy BMI, parity, mother's education and newborn sex, no relationship was observed between tertile of U-tAs and the birth outcomes considered, although we found an apparent but statistically non-significant dose-response relationship for small-for-gestational-age 2.38% ( 95% CI 0.003, 0.16), versus 7.32% (95% CI 0.02, 0.21%), versus 8.57% (0.03, 0.25%). This finding requires further evaluation considering other factors such as metabolic arsenic species, additional maternal covariates and ethnicity. en_US
dc.language.iso eng
dc.publisher Springer
dc.relation.ispartofseries Exposure and Health
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject World Health Organization en_US
dc.subject risk assessment en_US
dc.subject child health en_US
dc.subject drinking water en_US
dc.subject pregnancy en_US
dc.subject public health en_US
dc.subject age structure en_US
dc.subject arsenic en_US
dc.subject Arsenic exposure en_US
dc.subject Birth outcomes en_US
dc.subject concentration (composition) en_US
dc.subject dose-response relationship en_US
dc.subject ethnicity en_US
dc.subject spatiotemporal analysis en_US
dc.subject Tacna en_US
dc.subject Urinary arsenic en_US
dc.subject womens health en_US
dc.title Total Urinary Arsenic and Inorganic Arsenic Concentrations and Birth Outcomes in Pregnant Women of Tacna, Peru: A Cross-Sectional Study en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1007/s12403-020-00377-2
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#5.07.01
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.05
dc.relation.issn 2451-9685

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