HDL colesterol bajo como factor de riesgo cardiovascular en población rural, urbana y rural urbana migrante: Peru Migrant

Lazo Porras, Maria de los Angeles

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dc.contributor.advisor	Miranda Montero, Juan Jaime	es_ES
dc.contributor.author	Lazo Porras, Maria de los Angeles	es_ES
dc.date.accessioned	2017-12-15T17:48:19Z
dc.date.available	2017-12-15T17:48:19Z
dc.date.issued	2016
dc.identifier.uri	https://hdl.handle.net/20.500.12866/929
dc.description.abstract	Introduction: Whilst the relationship between lipids and cardiovascular mortality has been well studied and appears to be controversial, very little has been explored in the context of rural-to-urban migration in low-resource settings. Objective: Determine the profile and related factors for HDL-c patterns (isolated and nonisolated low HDL-c) in three population-based groups according to their migration status, and determine the effect of HDL-c patterns on the rates of cardiovascular outcomes (i.e. non-fatal stroke and non-fatal myocardial infarction) and mortality. Methods: Cross-sectional and 5-year longitudinal data from the PERU MIGRANT study, designed to assess the effect of migration on cardiovascular risk profiles and mortality in Peru. Two different analyses were performed: first, we estimated prevalence and associated factors with isolated and non-isolated low HDL-c at baseline. Second, using longitudinal information, relative risk ratios (RRR) of composite outcomes of mortality, non-fatal stroke and non-fatal myocardial infarction were calculated according to HDL-c levels at baseline. Results: Data from 988 participants, rural (n=201), rural-to-urban migrants (n=589), and urban (n=199) groups, was analysed. Low HDL-c was present in 56.5% (95%CI: 53.4%– 59.6%) without differences by study groups. Isolated low HDL-c was found in 36.5% (95%CI: 33.5–39.5%), with differences between study groups. In multivariable analysis, urban group (vs. rural), female gender, overweight and obesity were independently associated with isolated low HDL-c. Only female gender, overweight and obesity were associated with non-isolated low HDL-c. Longitudinal analyses showed that non-isolated low HDL-c increased the risk of negative cardiovascular outcomes (RRR=3.46; 95%CI: 1.23–9.74). Conclusions: Isolated low HDL-c was the most common dyslipidaemia in the study population and was more frequent in rural subjects. Non-isolated low HDL-c increased three- to fourfold the 5-year risk of cardiovascular outcomes.	en_US
dc.format	application/pdf	es_ES
dc.language.iso	eng	es_ES
dc.publisher	Universidad Peruana Cayetano Heredia	es_ES
dc.rights	info:eu-repo/semantics/openAccess	es_ES
dc.rights.uri	https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es	es_ES
dc.subject	HDL-Colesterol	es_ES
dc.subject	Migración Humana	es_ES
dc.subject	Infarto del Miocardio	es_ES
dc.subject	Accidente Cerebrovascular	es_ES
dc.subject	Factores de Riesgo	es_ES
dc.subject	Estudios Longitudinales	es_ES
dc.title	HDL colesterol bajo como factor de riesgo cardiovascular en población rural, urbana y rural urbana migrante: Peru Migrant	es_ES
dc.title.alternative	Low HDL cholesterol as a cardiovascular risk factor in rural, urban, and rural-urbanvmigrants: PERU MIGRANT cohort study	en_US
dc.type	info:eu-repo/semantics/masterThesis	es_ES
thesis.degree.name	Maestro en Ciencias en Investigación Epidemiológica	es_ES
thesis.degree.grantor	Universidad Peruana Cayetano Heredia. Escuela de Posgrado Víctor Alzamora Castro	es_ES
thesis.degree.discipline	Ciencias en Investigación Epidemiológica	es_ES
dc.publisher.country	PE	es_ES
dc.subject.ocde	https://purl.org/pe-repo/ocde/ford#3.03.09	es_ES
renati.type	http://purl.org/pe-repo/renati/type#tesis	es_ES
renati.level	http://purl.org/pe-repo/renati/level#maestro	es_ES
renati.discipline	021097	es_ES