Universidad Peruana Cayetano Heredia

An open dataset of Plasmodium falciparum genome variation in 7,000 worldwide samples

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dc.contributor.author Ahouidi, A.
dc.contributor.author Ali, M.
dc.contributor.author Almagro-Garcia, J.
dc.contributor.author Amambua-Ngwa, A.
dc.contributor.author Amaratunga, C.
dc.contributor.author Amato, R.
dc.contributor.author Amenga-Etego, L.
dc.contributor.author Andagalu, B.
dc.contributor.author Anderson, T.J.C.
dc.contributor.author Andrianaranjaka, V.
dc.contributor.author Apinjoh, T.
dc.contributor.author Ariani, C.
dc.contributor.author Ashley, E.A.
dc.contributor.author Auburn, S.
dc.contributor.author Awandare, G.
dc.contributor.author Ba, H.
dc.contributor.author Baraka, V.
dc.contributor.author Barry, A.E.
dc.contributor.author Bejon, P.
dc.contributor.author Bertin, G.I.
dc.contributor.author Boni, M.F.
dc.contributor.author Borrmann, S.
dc.contributor.author Bousema, T.
dc.contributor.author Branch, O.
dc.contributor.author Bull, P.C.
dc.contributor.author Busby, G.B.J.
dc.contributor.author Chookajorn, T.
dc.contributor.author Chotivanich, K.
dc.contributor.author Claessens, A.
dc.contributor.author Conway, D.
dc.contributor.author Craig, A.
dc.contributor.author D'Alessandro, U.
dc.contributor.author Dama, S.
dc.contributor.author Day, N.P.J.
dc.contributor.author Denis, B.
dc.contributor.author Diakite, M.
dc.contributor.author Djimdé, A.
dc.contributor.author Dolecek, C.
dc.contributor.author Dondorp, A.M.
dc.contributor.author Drakeley, C.
dc.contributor.author Drury, E.
dc.contributor.author Duffy, P.
dc.contributor.author Echeverry, D.F.
dc.contributor.author Egwang, T.G.
dc.contributor.author Erko, B.
dc.contributor.author Fairhurst, R.M.
dc.contributor.author Faiz, A.
dc.contributor.author Fanello, C.A.
dc.contributor.author Fukuda, M.M.
dc.contributor.author Gamboa Vilela, Dionicia Baziliza
dc.contributor.author Ghansah, A.
dc.contributor.author Golassa, L.
dc.contributor.author Goncalves, S.
dc.contributor.author Hamilton, W.L.
dc.contributor.author Harrison, G.L.A.
dc.contributor.author Hart, L.
dc.contributor.author Henrichs, C.
dc.contributor.author Hien, T.T.
dc.contributor.author Hill, C.A.
dc.contributor.author Hodgson, A.
dc.contributor.author Hubbart, C.
dc.contributor.author Imwong, M.
dc.contributor.author Ishengoma, D.S.
dc.contributor.author Jackson, S.A.
dc.contributor.author Jacob, C.G.
dc.contributor.author Jeffery, B.
dc.contributor.author Jeffreys, A.E.
dc.contributor.author Johnson, K.J.
dc.contributor.author Jyothi, D.
dc.contributor.author Kamaliddin, C.
dc.contributor.author Kamau, E.
dc.contributor.author Kekre, M.
dc.contributor.author Kluczynski, K.
dc.contributor.author Kochakarn, T.
dc.contributor.author Konaté, A.
dc.contributor.author Kwiatkowski, D.P.
dc.contributor.author Kyaw, M.P.
dc.contributor.author Lim, P.
dc.contributor.author Lon, C.
dc.contributor.author Loua, K.M.
dc.contributor.author Maïga-Ascofaré, O.
dc.contributor.author Malangone, C.
dc.contributor.author Manske, M.
dc.contributor.author Marfurt, J.
dc.contributor.author Marsh, K.
dc.contributor.author Mayxay, M.
dc.contributor.author Miles, A.
dc.contributor.author Miotto, O.
dc.contributor.author Mobegi, V.
dc.contributor.author Mokuolu, O.A.
dc.contributor.author Montgomery, J.
dc.contributor.author Mueller, I.
dc.contributor.author Newton, P.N.
dc.contributor.author Nguyen, T.
dc.contributor.author Nguyen, T.-N.
dc.contributor.author Noedl, H.
dc.contributor.author Nosten, F.
dc.contributor.author Noviyanti, R.
dc.contributor.author Nzila, A.
dc.contributor.author Ochola-Oyier, L.I.
dc.contributor.author Ocholla, H.
dc.contributor.author Oduro, A.
dc.contributor.author Omedo, I.
dc.contributor.author Onyamboko, M.A.
dc.contributor.author Ouedraogo, J.-B.
dc.contributor.author Oyebola, K.
dc.contributor.author Pearson, R.D.
dc.contributor.author Peshu, N.
dc.contributor.author Phyo, A.P.
dc.contributor.author Plowe, C.V.
dc.contributor.author Price, R.N.
dc.contributor.author Pukrittayakamee, S.
dc.contributor.author Randrianarivelojosia, M.
dc.contributor.author Rayner, J.C.
dc.contributor.author Ringwald, P.
dc.contributor.author Rockett, K.A.
dc.contributor.author Rowlands, K.
dc.contributor.author Ruiz, L.
dc.contributor.author Saunders, D.
dc.contributor.author Shayo, A.
dc.contributor.author Siba, P.
dc.contributor.author Simpson, V.J.
dc.contributor.author Stalker, J.
dc.contributor.author Su, X.-Z.
dc.contributor.author Sutherland, C.
dc.contributor.author Takala-Harrison, S.
dc.contributor.author Tavul, L.
dc.contributor.author Thathy, V.
dc.contributor.author Tshefu, A.
dc.contributor.author Verra, F.
dc.contributor.author Vinetz, Joseph Michael
dc.contributor.author Wellems, T.E.
dc.contributor.author Wendler, J.
dc.contributor.author White, N.J.
dc.contributor.author Wright, I.
dc.contributor.author Yavo, W.
dc.contributor.author Ye, H.
dc.contributor.author MalariaGEN
dc.date.accessioned 2021-05-18T21:44:14Z
dc.date.available 2021-05-18T21:44:14Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/9351
dc.description.abstract MalariaGEN is a data-sharing network that enables groups around the world to work together on the genomic epidemiology of malaria. Here we describe a new release of curated genome variation data on 7,000 Plasmodium falciparum samples from MalariaGEN partner studies in 28 malaria-endemic countries. High-quality genotype calls on 3 million single nucleotide polymorphisms (SNPs) and short indels were produced using a standardised analysis pipeline. Copy number variants associated with drug resistance and structural variants that cause failure of rapid diagnostic tests were also analysed. Almost all samples showed genetic evidence of resistance to at least one antimalarial drug, and some samples from Southeast Asia carried markers of resistance to six commonly-used drugs. Genes expressed during the mosquito stage of the parasite life-cycle are prominent among loci that show strong geographic differentiation. By continuing to enlarge this open data resource we aim to facilitate research into the evolutionary processes affecting malaria control and to accelerate development of the surveillance toolkit required for malaria elimination en_US
dc.language.iso eng
dc.publisher F1000 Research
dc.relation.ispartofseries Wellcome Open Research
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Malaria en_US
dc.subject Plasmodium falciparum en_US
dc.subject Drug resistance en_US
dc.subject Genomics en_US
dc.subject Population genetics en_US
dc.subject Data resource en_US
dc.subject Evolution en_US
dc.subject Genomic epidemiology en_US
dc.subject Rapid diagnostic test failure en_US
dc.title An open dataset of Plasmodium falciparum genome variation in 7,000 worldwide samples en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.12688/wellcomeopenres.16168.1
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.03
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.00.00
dc.relation.issn 2398-502X


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