Universidad Peruana Cayetano Heredia

Antimicrobial Resistance Patterns and Dynamics of Extended-Spectrum beta-Lactamase-Producing Uropathogenic Escherichia coli in Cusco, Peru

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dc.contributor.author Loyola Sosa, Steev Orlando
dc.contributor.author Concha-Velasco, Fatima
dc.contributor.author Pino-Duenas, Jimena
dc.contributor.author Vasquez-Luna, Nancy
dc.contributor.author Juarez, Paola
dc.contributor.author Llanos, Carlos
dc.contributor.author Salvatierra, Guillermo
dc.contributor.author Tamariz, Jesus
dc.contributor.author Lescano Guevara, Andres Guillermo
dc.date.accessioned 2021-05-18T21:44:14Z
dc.date.available 2021-05-18T21:44:14Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/9353
dc.description.abstract Urinary tract infections (UTIs) are a common human infection. Antibiotic resistance in extended-spectrum beta-lactamase (ESBL)-producing uropathogenic E. coli (UPEC) is a major therapeutic challenge due to limited treatment alternatives. The aim was to characterize the antimicrobial resistance (AMR) and dynamics of ESBL-producing UPEC isolates from UTI cases seen at a local hospital in Cusco, Peru. Ninety-nine isolates from respective patients were characterized against 18 different antibiotics. Latent class analysis (LCA) was used to evaluate the dynamics across the study time according to resistance patterns. The median age of patients was 51 years old, and nearly half were women. ESBL-producing UPEC isolates were slightly more frequent in outpatient services than emergency rooms, and there were higher resistance rates in males compared to females. Half of the ESBL producers were resistant to aminoglycosides and nitrofurantoin. Cefoxitin and fosfomycin resistance was 29.3% and 14.1%, respectively. Resistance to carbapenems was not observed. All isolates were multidrug-resistant bacteria, and 16.2% (16/99) were also classified as extensively drug-resistant bacteria. The resistance patterns varied across the study time and differed regarding sex and healthcare service. The study revealed high levels of AMR to commonly used antimicrobials and a dynamic circulation of ESBL-producing UPEC isolates with varying resistance patterns en_US
dc.language.iso eng
dc.publisher MDPI
dc.relation.ispartofseries Antibiotics
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject urinary tract infections; Escherichia coli; β-lactamases; β-lactam resistance; extended-spectrum β-lactamase en_US
dc.title Antimicrobial Resistance Patterns and Dynamics of Extended-Spectrum beta-Lactamase-Producing Uropathogenic Escherichia coli in Cusco, Peru en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.3390/antibiotics10050485
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.03
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.01
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.01.055
dc.relation.issn 2079-6382


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