Universidad Peruana Cayetano Heredia

Blood lead levels in Peruvian adults are associated with proximity to mining and DNA methylation

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dc.contributor.author Childebayeva, A.
dc.contributor.author Goodrich, J.M.
dc.contributor.author Chesterman, N.
dc.contributor.author León-Velarde, Fabiola
dc.contributor.author Rivera Chira, Maria Concepcion
dc.contributor.author Kiyamu Tsuchiya, Melisa
dc.contributor.author Brutsaert, T.D.
dc.contributor.author Bigham, A.W.
dc.contributor.author Dolinoy, D.C.
dc.date.accessioned 2021-05-18T21:44:14Z
dc.date.available 2021-05-18T21:44:14Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/9355
dc.description.abstract Background: Inorganic lead (Pb) is common in the environment, and is toxic to neurological, renal, and cardiovascular systems. Pb exposure influences the epigenome with documented effects on DNA methylation (DNAm). We assessed the impact of low levels of Pb exposure on DNAm among non-miner individuals from two locations in Peru: Lima, the capital, and Cerro de Pasco, a highland mining town, to study the effects of Pb exposure on physiological outcomes and DNAm. Methods: Pb levels were measured in whole blood (n = 305). Blood leukocyte DNAm was determined for 90 DNA samples using the Illumina MethylationEPIC chip. An epigenome-wide association study was performed to assess the relationship between Pb and DNAm. Results: Individuals from Cerro de Pasco had higher Pb than individuals from Lima (p-value = 2.00E-16). Males had higher Pb than females (p-value = 2.36E-04). Pb was positively associated with hemoglobin (p-value = 8.60E-04). In Cerro de Pasco, blood Pb decreased with the distance from the mine (p-value = 0.04), and association with soil Pb was approaching significance (p-value = 0.08). We identified differentially methylated positions (DMPs) associated with genes SOX18, ZMIZ1, and KDM1A linked to neurological function. We also found 45 differentially methylated regions (DMRs), seven of which were associated with genes involved in metal ion binding and nine to neurological function and development. Conclusions: Our results demonstrate that even low levels of Pb can have a significant impact on the body including changes to DNAm. We report associations between Pb and hemoglobin, Pb and distance from mining, and between blood and soil Pb. We also report associations between loci- and region-specific DNAm and Pb en_US
dc.language.iso eng
dc.publisher Elsevier
dc.relation.ispartofseries Environment International
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Andes en_US
dc.subject Hemoglobin en_US
dc.subject DNA methylation en_US
dc.subject EWAS en_US
dc.subject Lead (Pb) en_US
dc.subject Mining en_US
dc.title Blood lead levels in Peruvian adults are associated with proximity to mining and DNA methylation en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1016/j.envint.2021.106587
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.05.08
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.05
dc.relation.issn 1873-6750


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