Universidad Peruana Cayetano Heredia

Changes in inflammatory gene expression in brain tissue adjacent and distant to a viable cyst in a rat model for neurocysticercosis

Mostrar el registro sencillo del ítem

dc.contributor.author Carmen-Orozco, Rogger P.
dc.contributor.author Dávila-Villacorta, Danitza G.
dc.contributor.author Delgado-Kamiche, Ana D.
dc.contributor.author Celiz, Rensson H.
dc.contributor.author Trompeter, Grace
dc.contributor.author Sutherland, Graham
dc.contributor.author Gavídia, Cesar
dc.contributor.author García Lescano, Héctor Hugo
dc.contributor.author Gilman, Robert Hugh
dc.contributor.author Verastegui Pimentel, Manuela Renee
dc.date.accessioned 2021-05-18T21:44:14Z
dc.date.available 2021-05-18T21:44:14Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/9356
dc.description.abstract BACKGROUND: The parasite Taenia solium causes neurocysticercosis (NCC) in humans and is a common cause of adult-onset epilepsy in the developing world. Hippocampal atrophy, which occurs far from the cyst, is an emerging new complication of NCC. Evaluation of molecular pathways in brain regions close to and distant from the cyst could offer insight into this pathology. METHODS: Rats were inoculated intracranially with T. solium oncospheres. After 4 months, RNA was extracted from brain tissue samples in rats with NCC and uninfected controls, and cDNA was generated. Expression of 38 genes related to different molecular pathways involved in the inflammatory response and healing was assessed by RT-PCR array. RESULTS: Inflammatory cytokines IFN-γ, TNF-α, and IL-1, together with TGF-β and ARG-1, were overexpressed in tissue close to the parasite compared to non-infected tissue. Genes for IL-1A, CSF-1, FN-1, COL-3A1, and MMP-2 were overexpressed in contralateral tissue compared to non-infected tissue. CONCLUSIONS: The viable cysticerci in the rat model for NCC is characterized by increased expression of genes associated with a proinflammatory response and fibrosis-related proteins, which may mediate the chronic state of infection. These pathways appear to influence regions far from the cyst, which may explain the emerging association between NCC and hippocampal atrophy en_US
dc.language.iso eng
dc.publisher Public Library of Science
dc.relation.ispartofseries PLoS Neglected Tropical Diseases
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Gene expression en_US
dc.subject Inflammation en_US
dc.subject Parasitic diseases en_US
dc.subject Cytokines en_US
dc.subject Hippocampus en_US
dc.subject Atrophy en_US
dc.subject Metabolic pathways en_US
dc.subject Fibrosis en_US
dc.title Changes in inflammatory gene expression in brain tissue adjacent and distant to a viable cyst in a rat model for neurocysticercosis en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1371/journal.pntd.0009295
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.06
dc.relation.issn 1935-2735


Ficheros en el ítem

Ficheros Tamaño Formato Ver

No hay ficheros asociados a este ítem.

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem

info:eu-repo/semantics/restrictedAccess Excepto si se señala otra cosa, la licencia del ítem se describe como info:eu-repo/semantics/restrictedAccess

Buscar en el Repositorio


Listar

Panel de Control

Estadísticas