Universidad Peruana Cayetano Heredia

Exaggerated IL-17A activity in human in vivo recall responses discriminates active tuberculosis from latent infection and cured disease.

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dc.contributor.author Pollara, Gabriele
dc.contributor.author Turner, Carolin T.
dc.contributor.author Rosenheim, Joshua
dc.contributor.author Chandran, Aneesh
dc.contributor.author Bell, Lucy C. K.
dc.contributor.author Khan, Ayesha
dc.contributor.author Patel, Amit
dc.contributor.author Peralta, Luis Felipe
dc.contributor.author Folino, Anna
dc.contributor.author Akarca, Ayse
dc.contributor.author Venturini, Cristina
dc.contributor.author Baker, Tina
dc.contributor.author Ecker, Simone
dc.contributor.author Ricciardolo, Fabio L. M.
dc.contributor.author Marafioti, Teresa
dc.contributor.author Ugarte Gil, Cesar Augusto
dc.contributor.author Moore, David Alexander James
dc.contributor.author Chain, Benjamin M.
dc.contributor.author Tomlinson, Gillian S.
dc.contributor.author Noursadeghi, Mahdad
dc.date.accessioned 2021-05-18T21:44:15Z
dc.date.available 2021-05-18T21:44:15Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/9370
dc.description.abstract Host immune responses at the site of Mycobacterium tuberculosis infection can mediate pathogenesis of tuberculosis (TB) and onward transmission of infection. We hypothesized that pathological immune responses would be enriched at the site of host-pathogen interactions modeled by a standardized tuberculin skin test (TST) challenge in patients with active TB compared to those without disease, and interrogated immune responses by genome-wide transcriptional profiling. We show exaggerated interleukin-17A (IL-17A) and T helper 17 (T(H)17) responses among 48 individuals with active TB compared to 191 with latent TB infection, associated with increased neutrophil recruitment and matrix metalloproteinase-1 expression, both involved in TB pathogenesis. Curative antimicrobial treatment reversed these observed changes. Increased IL-1β and IL-6 responses to mycobacterial stimulation were evident both in circulating monocytes and in molecular changes at the site of TST in individuals with active TB, supporting a model in which monocyte-derived IL-1β and IL-6 promote T(H)17 differentiation within tissues. Modulation of these cytokine pathways may provide a rational strategy for host-directed therapy in active TB en_US
dc.language.iso eng
dc.publisher American Association for the Advancement of Science
dc.relation.ispartofseries Science Translational Medicine
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject IL-17A en_US
dc.subject human in vivo en_US
dc.subject tuberculosis en_US
dc.subject infection en_US
dc.subject cured disease en_US
dc.title Exaggerated IL-17A activity in human in vivo recall responses discriminates active tuberculosis from latent infection and cured disease. en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1126/scitranslmed.abg7673
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.00
dc.relation.issn 1946-6242


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