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Genomic Characterization of Campylobacter jejuni Adapted to the Guinea Pig (Cavia porcellus) Host

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dc.contributor.author Parker, Craig T.
dc.contributor.author Cooper, Kerry K.
dc.contributor.author Schiaffino Salazar, Francesca
dc.contributor.author Miller, William G.
dc.contributor.author Huynh, Steven
dc.contributor.author Gray, Hannah K.
dc.contributor.author Olortegui, Maribel Paredes
dc.contributor.author Bardales, Paul Garcia
dc.contributor.author Trigoso, Dixner Rengifo
dc.contributor.author Penataro-Yori, Pablo
dc.contributor.author Kosek, Margaret N.
dc.date.accessioned 2021-05-18T21:44:15Z
dc.date.available 2021-05-18T21:44:15Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/9375
dc.description.abstract Campylobacter jejuni is the leading bacterial cause of gastroenteritis worldwide with excessive incidence in low-and middle-income countries (LMIC). During a survey for C. jejuni from putative animal hosts in a town in the Peruvian Amazon, we were able to isolate and whole genome sequence two C. jejuni strains from domesticated guinea pigs (Cavia porcellus). The C. jejuni isolated from guinea pigs had a novel multilocus sequence type that shared some alleles with other C. jejuni collected from guinea pigs. Average nucleotide identity and phylogenetic analysis with a collection of C. jejuni subsp. jejuni and C. jejuni subsp. doylei suggest that the guinea pig isolates are distinct. Genomic comparisons demonstrated gene gain and loss that could be associated with guinea pig host specialization related to guinea pig diet, anatomy, and physiology including the deletion of genes involved with selenium metabolism, including genes encoding the selenocysteine insertion machinery and selenocysteine-containing proteins en_US
dc.language.iso eng
dc.publisher Frontiers Media
dc.relation.ispartofseries Frontiers in Cellular and Infection Microbiology
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject gastroenteritis en_US
dc.subject campylobacteriosis en_US
dc.subject Campylobacter jejuni en_US
dc.subject selenocysteine en_US
dc.subject source attribution en_US
dc.title Genomic Characterization of Campylobacter jejuni Adapted to the Guinea Pig (Cavia porcellus) Host en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.3389/fcimb.2021.607747
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.08
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#1.06.01
dc.relation.issn 2235-2988


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