Universidad Peruana Cayetano Heredia

Oil emulsion from Plukenetia huayllabambana (Sacha inchi) modifies nitric oxide and leptin in the liver and antioxidant and inflammation markers in the adipose tissue in obese rats

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dc.contributor.author Ambulay, J.P.
dc.contributor.author Rojas, P.A.
dc.contributor.author Timoteo, O.S.
dc.contributor.author Barreto, T.V.
dc.contributor.author Vila, Z.N.
dc.contributor.author de los Santos, M.B.
dc.contributor.author Eguiluz, M.
dc.contributor.author Colarossi, A.
dc.date.accessioned 2021-05-18T21:44:16Z
dc.date.available 2021-05-18T21:44:16Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/9392
dc.description.abstract Background: Obesity is characterized by excessive accumulation of adipose tissue and is associated with higher risk of metabolic diseases and other comorbidities. Efficacious strategies including a diet high in “functional foods” are promising. Plukenetia huayllabambana known as Sacha Inchi (SI), is a legume which seeds are rich in proteins, tocopherols, and fatty acids such as omega-3 (ω-3). The latter has emerged as a potential protective nutrient against the cardiometabolic risks associated with obesity. Omega-3 changes the membrane lipid profile of hepatic and adipose cells triggering the expression of antioxidant and anti-inflammatory genes. However, there are few reports in relation to the effect of these oils in inflammatory and stress response related to obesity. In this sense, the present study evaluated the effect of SI oil emulsion on nitric oxide and leptin levels in the liver and some markers of oxidative stress and inflammation in adipose tissue from the rodent obesity model. Methods: Six groups were formed: Not obese control group (Noc), obese control (Oc), two groups treated with the emulsion of SI oil (Os1:0.25g ω-3/day; Os2:0.5g ω-3/day), one obese group treated with atorvastatin (Oa) and one group treated with atorvastatin plus the emulsion of SI oil (Oas2). Results: Os1 and Os2 lowered nitric oxide and increased liver leptin levels. In the adipose tissue, the superoxide dismutase and reducing antioxidant power increased significantly in Os1 and Os2 groups. The anti-inflammatory marker IL-4 was also increased in Os2, Oa and Oas2 compared to the Oc and IL-10 increased in Oas2 group. Conclusion: Our study suggests that the emulsion of SI oil can modify the inflammatory and stress responses associated with obesity and it can be incorporated as a promising functional food en_US
dc.language.iso eng
dc.publisher Food Science Publisher
dc.relation.ispartofseries Functional Foods in Health and Disease
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Article en_US
dc.subject controlled study en_US
dc.subject male en_US
dc.subject nitric oxide en_US
dc.subject oxidative stress en_US
dc.subject nonhuman en_US
dc.subject animal experiment en_US
dc.subject animal model en_US
dc.subject inflammation en_US
dc.subject Obesity en_US
dc.subject obesity en_US
dc.subject animal tissue en_US
dc.subject antioxidant en_US
dc.subject malonaldehyde en_US
dc.subject rat en_US
dc.subject superoxide dismutase en_US
dc.subject Inflammation en_US
dc.subject Oxidative stress en_US
dc.subject antioxidant activity en_US
dc.subject linoleic acid en_US
dc.subject linolenic acid en_US
dc.subject adipose tissue en_US
dc.subject animal cell en_US
dc.subject antiinflammatory activity en_US
dc.subject antiinflammatory agent en_US
dc.subject atorvastatin en_US
dc.subject diet-induced obesity en_US
dc.subject emulsion en_US
dc.subject enzyme activity en_US
dc.subject epididymis fat en_US
dc.subject functional food en_US
dc.subject high performance liquid chromatography en_US
dc.subject interleukin 10 en_US
dc.subject interleukin 4 en_US
dc.subject legume en_US
dc.subject leptin en_US
dc.subject Leptin en_US
dc.subject lipid liver level en_US
dc.subject lipid metabolism en_US
dc.subject lipid oxidation en_US
dc.subject liquid nitrogen en_US
dc.subject liver level en_US
dc.subject Nitric oxide en_US
dc.subject oleic acid en_US
dc.subject omega 3 fatty acid en_US
dc.subject palmitic acid en_US
dc.subject plant seed en_US
dc.subject Plukenetia huayllabambana en_US
dc.subject Sacha inchi oil emulsion en_US
dc.subject SI oil emulsion en_US
dc.subject stearic acid en_US
dc.subject tumor necrosis factor en_US
dc.subject unclassified drug en_US
dc.subject vegetable oil en_US
dc.title Oil emulsion from Plukenetia huayllabambana (Sacha inchi) modifies nitric oxide and leptin in the liver and antioxidant and inflammation markers in the adipose tissue in obese rats en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.31989/FFHD.V11I3.778
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.04
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#4.04.01
dc.relation.issn 2160-3855


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