dc.contributor.author |
Judge, Conor |
|
dc.contributor.author |
O'Donnell, Martin J. |
|
dc.contributor.author |
Hankey, Graeme J. |
|
dc.contributor.author |
Rangarajan, Sumathy |
|
dc.contributor.author |
Chin, Siu Lim |
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dc.contributor.author |
Rao-Melacini, Purnima |
|
dc.contributor.author |
Ferguson, John |
|
dc.contributor.author |
Smyth, Andrew |
|
dc.contributor.author |
Xavier, Denis |
|
dc.contributor.author |
Lisheng, Liu |
|
dc.contributor.author |
Zhang, Hongye |
|
dc.contributor.author |
Lopez-Jaramillo, Patricio |
|
dc.contributor.author |
Damasceno, Albertino |
|
dc.contributor.author |
Langhorne, Peter |
|
dc.contributor.author |
Rosengren, Annika |
|
dc.contributor.author |
Dans, Antonio L. |
|
dc.contributor.author |
Elsayed, Ahmed |
|
dc.contributor.author |
Avezum, Alvaro |
|
dc.contributor.author |
Mondo, Charles |
|
dc.contributor.author |
Ryglewicz, Danuta |
|
dc.contributor.author |
Czlonkowska, Anna |
|
dc.contributor.author |
Pogosova, Nana |
|
dc.contributor.author |
Weimar, Christian |
|
dc.contributor.author |
Diaz, Rafael |
|
dc.contributor.author |
Yusoff, Khalid |
|
dc.contributor.author |
Yusufali, Afzalhussein |
|
dc.contributor.author |
Oguz, Aytekin |
|
dc.contributor.author |
Wang, Xingyu |
|
dc.contributor.author |
Lanas, Fernando |
|
dc.contributor.author |
Ogah, Okechukwu S. |
|
dc.contributor.author |
Ogunniyi, Adesola |
|
dc.contributor.author |
Iversen, Helle K. |
|
dc.contributor.author |
Málaga Rodríguez, Germán Javier |
|
dc.contributor.author |
Rumboldt, Zvonko |
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dc.contributor.author |
Oveisgharan, Shahram |
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dc.contributor.author |
Al Hussain, Fawaz |
|
dc.contributor.author |
Yusuf, Salim |
|
dc.date.accessioned |
2021-05-18T21:44:17Z |
|
dc.date.available |
2021-05-18T21:44:17Z |
|
dc.date.issued |
2021 |
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dc.identifier.uri |
https://hdl.handle.net/20.500.12866/9410 |
|
dc.description.abstract |
BACKGROUND: Although low sodium intake (<2 g/day) and high potassium intake (>3.5 g/day) are proposed as public health interventions to reduce stroke risk, there is uncertainty about the benefit and feasibility of this combined recommendation on prevention of stroke. METHODS: We obtained random urine samples from 9,275 cases of acute first stroke and 9,726 matched controls from 27 countries and estimated the 24-hour sodium and potassium excretion, a surrogate for intake, using the Tanaka formula. Using multivariable conditional logistic regression, we determined the associations of estimated 24-hour urinary sodium and potassium excretion with stroke and its subtypes. RESULTS: Compared with an estimated urinary sodium excretion of 2.8-3.5 g/day (reference), higher (>4.26 g/day) (odds ratio [OR] 1.81; 95% confidence interval [CI], 1.65-2.00) and lower (<2.8 g/day) sodium excretion (OR 1.39; 95% CI, 1.26-1.53) were significantly associated with increased risk of stroke. The stroke risk associated with the highest quartile of sodium intake (sodium excretion >4.26 g/day) was significantly greater (P < 0.001) for intracerebral hemorrhage (ICH) (OR 2.38; 95% CI, 1.93-2.92) than for ischemic stroke (OR 1.67; 95% CI, 1.50-1.87). Urinary potassium was inversely and linearly associated with risk of stroke, and stronger for ischemic stroke than ICH (P = 0.026). In an analysis of combined sodium and potassium excretion, the combination of high potassium intake (>1.58 g/day) and moderate sodium intake (2.8-3.5 g/day) was associated with the lowest risk of stroke. CONCLUSIONS: The association of sodium intake and stroke is J-shaped, with high sodium intake a stronger risk factor for ICH than ischemic stroke. Our data suggest that moderate sodium intake-rather than low sodium intake-combined with high potassium intake may be associated with the lowest risk of stroke and expected to be a more feasible combined dietary target |
en_US |
dc.language.iso |
eng |
|
dc.publisher |
Oxford University Press |
|
dc.relation.ispartofseries |
American Journal of Hypertension |
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dc.rights |
info:eu-repo/semantics/restrictedAccess |
|
dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
|
dc.subject |
blood pressure |
en_US |
dc.subject |
hypertension |
en_US |
dc.subject |
intracerebral hemorrhage |
en_US |
dc.subject |
ischemic stroke |
en_US |
dc.subject |
potassium |
en_US |
dc.subject |
sodium |
en_US |
dc.subject |
stroke |
en_US |
dc.title |
Urinary Sodium and Potassium, and Risk of Ischemic and Hemorrhagic Stroke (INTERSTROKE): A Case-Control Study. |
en_US |
dc.type |
info:eu-repo/semantics/article |
|
dc.identifier.doi |
https://doi.org/10.1093/ajh/hpaa176 |
|
dc.subject.ocde |
https://purl.org/pe-repo/ocde/ford#3.02.27 |
|
dc.relation.issn |
1941-7225 |
|