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Effects of chronic intermittent hypobaric hypoxia on prostate-specific antigen (PSA) in Chilean miners

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dc.contributor.author Alcántara Zapata, Diana Elizabeth
dc.contributor.author Bangdiwala, Shrikant I.
dc.contributor.author Jiménez, Daniel
dc.contributor.author Kogevinas, Manolis
dc.contributor.author Marchetti, Nella
dc.contributor.author Nazzal, Carolina
dc.date.accessioned 2021-06-08T15:46:13Z
dc.date.available 2021-06-08T15:46:13Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/9487
dc.description.abstract OBJECTIVE: The aim was to determine the effects of chronic intermittent hypobaric hypoxia (CIHH) on prostate-specific antigen (PSA) levels in Chilean miners who work at different altitudes. METHODS: A cross-sectional study was conducted between April and July 2019. Miners from five mines (N=338) at different altitudes were evaluated. We recorded sociodemographic, working and altitude information. Haemoglobin oxygen saturation (SaO(2)) and haemoglobin (Hb) were measured in situ, while PSA and testosterone were analysed at a low level. Linear mixed-effect models were used to evaluate the association between PSA level and two CIHH exposures: composite CIHH (with four descriptors) and ChileStd-CIHH (CIHH Chilean standard; based on the Chilean technical guide for occupational exposure to CIHH). All models were adjusted by age, body mass index and day of the work the samples were taken. RESULTS: Highest and lowest PSA levels were found in mines ≥3000 m above sea level (mine 3: median=0.75, IQR=-0.45; mine 4: median=0.46, IQR=-0.35). In the multilevel models, the wider altitude difference between mining operation and camp showed lower PSA levels (model D: βPSA=-0.93 ng/mL, β(logPSA)=-0.07, p<0001), adjusted for other CIHH descriptors, SaO(2), Hb and testosterone. The descriptors of composite CIHH explained better PSA variations than ChileStd-CIHH (model D: marginal R(2)=0.090 vs model A: marginal R(2)=0.016). CONCLUSIONS: Occupational health regulations and high altitude medicine should consider these results as initial evidence on the inclusion of new descriptors for CIHH and the possible effect of this exposure on PSA levels in this male-dominated occupational sector en_US
dc.language.iso eng
dc.publisher BMJ Publishing Group
dc.relation.ispartofseries Occupational and Environmental Medicine
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject occupational health en_US
dc.subject environment en_US
dc.subject miners en_US
dc.subject public health surveillance en_US
dc.subject urology en_US
dc.title Effects of chronic intermittent hypobaric hypoxia on prostate-specific antigen (PSA) in Chilean miners en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1136/oemed-2020-107232
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.03.05
dc.relation.issn 1470-7926


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