dc.contributor.author |
Barile-Fabris, Leonor A. |
|
dc.contributor.author |
Fragoso-Loyo, Hilda |
|
dc.contributor.author |
Wojdyla, Daniel |
|
dc.contributor.author |
Quintana, Rosana |
|
dc.contributor.author |
Pons-Estel, Guillermo J. |
|
dc.contributor.author |
Catoggio, Luis J. |
|
dc.contributor.author |
Garcia, Mercedes A. |
|
dc.contributor.author |
Saurit, Veronica |
|
dc.contributor.author |
Drenkard, Cristina |
|
dc.contributor.author |
Bonfa, Eloisa |
|
dc.contributor.author |
Borba, Eduardo F. |
|
dc.contributor.author |
Sato, Emilia |
|
dc.contributor.author |
Tavares-Brenol, Joao C. |
|
dc.contributor.author |
Cavalcanti, Fernando |
|
dc.contributor.author |
Da Silva, Nilzio A. |
|
dc.contributor.author |
Lavras-Costallat, Lilian T. |
|
dc.contributor.author |
Guibert-Toledano, Marlene |
|
dc.contributor.author |
Massardo, Loreto |
|
dc.contributor.author |
Neira, Oscar |
|
dc.contributor.author |
Cardiel, Mario H. |
|
dc.contributor.author |
Amigo, Mary Carmen |
|
dc.contributor.author |
Garcia-De-La-Torre, Ignacio |
|
dc.contributor.author |
Silveira, Luis H. |
|
dc.contributor.author |
Acevedo-Vasquez, Eduardo M. |
|
dc.contributor.author |
Chacón-Díaz, Rosa |
|
dc.contributor.author |
Esteva-Spinetti, María H. |
|
dc.contributor.author |
Alarcón, Graciela S. |
|
dc.contributor.author |
Pons-Estel, Bernardo A. |
|
dc.date.accessioned |
2021-06-08T15:46:13Z |
|
dc.date.available |
2021-06-08T15:46:13Z |
|
dc.date.issued |
2021 |
|
dc.identifier.uri |
https://hdl.handle.net/20.500.12866/9489 |
|
dc.description.abstract |
INTRODUCTION: Factors related to presentation of neuropsychiatric (NP) SLE manifestations, early in the course of the disease, and during follow up have not been clearly established. PURPOSE: To identify disease and non-disease related factors associated with NP manifestations in early SLE. METHODS: We included 1193 patients from the GLADEL inception cohort free of NP involvement at cohort entry. We evaluated the association of demographic, clinical and laboratory data with NP involvement during follow-up. STATISTICAL METHODS: Independent factors associated with NP involvement were identified using a multivariable Cox regression model. RESULTS: Factors independently associated with NP manifestations were: mestizo ethnicity (HR 1.701, 95% CI 1.282-2.258, p=0.0002), myalgias/myositis (HR 1.832, 95% CI 1.335-2.515, p=0.0002), pneumonitis (HR 2.476, 95% CI 1.085-5.648, p=0.0312), shrinking lung (HR 2.428, 95% CI 1.074-5.493, p=0.0331) and hemolytic anemia (HR 1.629, 95% CI 1.130-2.347, p=0.0089). Longer disease duration at cohort entry (13 to 24months) was associated with a lower risk of developing NP manifestations (HR 0.642, 95% CI 0.441-0.934, p=0.0206). CONCLUSIONS: Patients with myalgias/myositis, pneumonitis, shrinking lung and hemolytic anemia are at higher risk of NP involvement, whereas longer disease duration at cohort entry is associated with a lower risk of developing NP involvement |
en_US |
dc.language.iso |
eng |
|
dc.publisher |
SAGE Publications |
|
dc.relation.ispartofseries |
Lupus |
|
dc.rights |
info:eu-repo/semantics/restrictedAccess |
|
dc.rights.uri |
https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es |
|
dc.subject |
Systemic lupus erythematosus |
en_US |
dc.subject |
neuropsychiatric manifestations |
en_US |
dc.subject |
prognostic factors |
en_US |
dc.title |
Factors associated with neuropsychiatric involvement in Latin American patients with systemic lupus erythematosus |
en_US |
dc.type |
info:eu-repo/semantics/article |
|
dc.identifier.doi |
https://doi.org/10.1177/09612033211020364 |
|
dc.subject.ocde |
https://purl.org/pe-repo/ocde/ford#3.02.17 |
|
dc.relation.issn |
1477-0962 |
|