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Factors associated with neuropsychiatric involvement in Latin American patients with systemic lupus erythematosus

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dc.contributor.author Barile-Fabris, Leonor A.
dc.contributor.author Fragoso-Loyo, Hilda
dc.contributor.author Wojdyla, Daniel
dc.contributor.author Quintana, Rosana
dc.contributor.author Pons-Estel, Guillermo J.
dc.contributor.author Catoggio, Luis J.
dc.contributor.author Garcia, Mercedes A.
dc.contributor.author Saurit, Veronica
dc.contributor.author Drenkard, Cristina
dc.contributor.author Bonfa, Eloisa
dc.contributor.author Borba, Eduardo F.
dc.contributor.author Sato, Emilia
dc.contributor.author Tavares-Brenol, Joao C.
dc.contributor.author Cavalcanti, Fernando
dc.contributor.author Da Silva, Nilzio A.
dc.contributor.author Lavras-Costallat, Lilian T.
dc.contributor.author Guibert-Toledano, Marlene
dc.contributor.author Massardo, Loreto
dc.contributor.author Neira, Oscar
dc.contributor.author Cardiel, Mario H.
dc.contributor.author Amigo, Mary Carmen
dc.contributor.author Garcia-De-La-Torre, Ignacio
dc.contributor.author Silveira, Luis H.
dc.contributor.author Acevedo-Vasquez, Eduardo M.
dc.contributor.author Chacón-Díaz, Rosa
dc.contributor.author Esteva-Spinetti, María H.
dc.contributor.author Alarcón, Graciela S.
dc.contributor.author Pons-Estel, Bernardo A.
dc.date.accessioned 2021-06-08T15:46:13Z
dc.date.available 2021-06-08T15:46:13Z
dc.date.issued 2021
dc.identifier.uri https://hdl.handle.net/20.500.12866/9489
dc.description.abstract INTRODUCTION: Factors related to presentation of neuropsychiatric (NP) SLE manifestations, early in the course of the disease, and during follow up have not been clearly established. PURPOSE: To identify disease and non-disease related factors associated with NP manifestations in early SLE. METHODS: We included 1193 patients from the GLADEL inception cohort free of NP involvement at cohort entry. We evaluated the association of demographic, clinical and laboratory data with NP involvement during follow-up. STATISTICAL METHODS: Independent factors associated with NP involvement were identified using a multivariable Cox regression model. RESULTS: Factors independently associated with NP manifestations were: mestizo ethnicity (HR 1.701, 95% CI 1.282-2.258, p=0.0002), myalgias/myositis (HR 1.832, 95% CI 1.335-2.515, p=0.0002), pneumonitis (HR 2.476, 95% CI 1.085-5.648, p=0.0312), shrinking lung (HR 2.428, 95% CI 1.074-5.493, p=0.0331) and hemolytic anemia (HR 1.629, 95% CI 1.130-2.347, p=0.0089). Longer disease duration at cohort entry (13 to 24months) was associated with a lower risk of developing NP manifestations (HR 0.642, 95% CI 0.441-0.934, p=0.0206). CONCLUSIONS: Patients with myalgias/myositis, pneumonitis, shrinking lung and hemolytic anemia are at higher risk of NP involvement, whereas longer disease duration at cohort entry is associated with a lower risk of developing NP involvement en_US
dc.language.iso eng
dc.publisher SAGE Publications
dc.relation.ispartofseries Lupus
dc.rights info:eu-repo/semantics/restrictedAccess
dc.rights.uri https://creativecommons.org/licenses/by-nc-nd/4.0/deed.es
dc.subject Systemic lupus erythematosus en_US
dc.subject neuropsychiatric manifestations en_US
dc.subject prognostic factors en_US
dc.title Factors associated with neuropsychiatric involvement in Latin American patients with systemic lupus erythematosus en_US
dc.type info:eu-repo/semantics/article
dc.identifier.doi https://doi.org/10.1177/09612033211020364
dc.subject.ocde https://purl.org/pe-repo/ocde/ford#3.02.17
dc.relation.issn 1477-0962

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